Evidence map›Paper›PMID 38939662›Full record

ArticleJACC. Advances2024

Feasibility and Findings of Including Self-Identified Adult Congenital Heart Disease Patients in the INVESTED Trial.

Payam Dehghani, Varun Srivatsav, Orly Vardeny, Jasmine Grewal, Alexander R Opotowsky, Isabelle Vonder Muhll, Michelle Keir, Robin Ducas, Jyotpal Singh, KyungMann Kim and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Payam DehghaniDivision of Cardiology, Department of Medicine, Prairie Vascular Research Inc, Regina, Saskatchewan, Canada.
Varun SrivatsavDepartment of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Orly VardenyMinneapolis VA Center for Care Delivery and Outcomes Research, University of Minnesota, Minneapolis, Minnesota, USA.
Jasmine GrewalDivision of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Alexander R OpotowskyDepartment of Pediatrics, Heart Institute, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Isabelle Vonder MuhllDivision of Cardiology, University of Alberta, Edmonton, Alberta, Canada.
Michelle KeirLibin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada.
Robin DucasSection of Cardiology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Jyotpal SinghDivision of Cardiology, Department of Medicine, Prairie Vascular Research Inc, Regina, Saskatchewan, Canada.
KyungMann KimDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jacob JosephCardiology Section, VA Providence Healthcare System, Providence, Rhode Island, USA.
Jamil AboulhosnAhmanson/UCLA Adult Congenital Heart Center, Ronald Reagan/UCLA Medical Center, Los Angeles, California, USA.
Tom HavighurstDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Sheila M HegdeDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Deepak L BhattMount Sinai Heart, Icahn School of Medicine at Mount Sinai Health System, New York, New York, USA.
Scott SolomonDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Michael FarkouhAcademic Affairs, Cedars-Sinai Health System, Los Angeles, California, USA.
Shaun G GoodmanDivision of Cardiology, St. Michael's Hospital, Unity Health Toronto, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Tabitha G MoeArizona Cardiology Group, University of Arizona College of Medicine-Phoenix, Phoenix, Arizona, USA.
Jacob A UdellFaculty of Medicine, Division of Cardiology, Department of Medicine, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Adult congenital heart disease (ACHD) patients have significant morbidity and rise in cardiac admissions. Their outcome with high-dose influenza vaccination is unknown in comparison to those without ACHD. Objectives: The purpose of this study was to compare all-cause mortality or cardiopulmonary hospitalizations in self-identified ACHD versus non-ACHD patients receiving high- or low-dose influenza vaccination within the INfluenza Vaccine to Effectively Stop cardioThoracic Events and Decompensated heart failure trial. Methods: We prospectively included ACHD patients in the INVESTED (INfluenza Vaccine to Effectively Stop cardioThoracic Events and Decompensated heart failure) trial. The primary endpoint was all-cause death or hospitalization for cardiovascular or pulmonary causes. Results: Of the 272 ACHD patients, 132 were randomly assigned to receive high-dose trivalent and 140 to standard-dose quadrivalent influenza vaccine. Compared to the non-ACHD cohort (n = 4,988), ACHD patients were more likely to be younger, women, smokers, have atrial fibrillation, and have a qualifying event of heart failure. The primary outcome was 49.8 events versus 42.8 events per 100 person-years (adjusted HR: 1.17; 95% CI: 0.95-1.45; Conclusions: Patients who self-identify as being ACHD had similar primary outcome of all-cause death or hospitalization for cardiovascular or pulmonary causes compared to non-ACHD cohort. High-dose influenza vaccination was similar to standard-dose influenza vaccination on the primary outcome in patients who self-identify as ACHD.

Indexed as

adult congenital heart diseaseinfluenzavaccination

Identifiers

PMID38939662
PMCPMC11198655

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.