ArticleJACC. Advances2024
Cardiac Damage Staging Predicts Outcomes in Aortic Valve Stenosis After Aortic Valve Replacement: Meta-Analysis.
Article in JACC. Advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Age and Procedural Timing for Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial.Circulation. Cardiovascular interventions · 2026Trial
- Acute bi-ventricular haemodynamic changes after transcatheter aortic valve implantation for severe aortic stenosis assessed using invasive pressure-volume loops.Cardiovascular intervention and therapeutics · 2026Article
- Cardiac damage stages at follow-up and subsequent clinical outcomes in patients with severe aortic stenosis.Cardiovascular intervention and therapeutics · 2026Article
- Association Between the Degree of Extravalvular Cardiac Damage and the Severity of Aortic Stenosis.JACC. Advances · 2026Article
- Staged Therapeutic Approach to Concomitant Severe Aortic Stenosis and Atrial Septal Defect: Addressing Dual Mechanisms of Heart Failure-Case Report and Literature Review.Life (Basel, Switzerland) · 2026Article
- Beyond Gradient, Beyond Flow: Rethinking Risk Stratification in Aortic Stenosis.Structural heart : the journal of the Heart Team · 2026Article
- Early Postrranscatheter Aortic Valve Replacement Heart Failure Hospitalization and Outcomes in Older Patients.Journal of the American Heart Association · 2026Article
- Impact of Extravalvular Remodeling on Wearable Smartwatch-Recorded Physical Activity in Patients Undergoing Transcatheter Aortic Valve Implantation for Severe Symptomatic Aortic Stenosis.Journal of the American Heart Association · 2026Article
- Aortic Stenosis-Associated Cardiac Damage: A Comparison Between Patients Treated with Surgery and Transcatheter Aortic Valve Replacement.Journal of clinical medicine · 2026Article
- External Validation of Two Different Cardiac Damage Staging Systems for Aortic Stenosis in Patients Treated with Surgical Aortic Valve Replacement.Journal of clinical medicine · 2026Article
- Multi-chamber three-dimensional myocardial strain assessment by computed tomography: a comparison with speckle tracking echocardiography and association with pulmonary hypertension in severe aortic stenosis.Frontiers in cardiovascular medicine · 2026Article
- Cardiac Damage Stages and Clinical Outcomes in Patients With Severe Aortic Stenosis.JACC. Advances · 2026Article
- Unsupervised machine learning analysis to enhance risk stratification in patients with asymptomatic aortic stenosis.European heart journal. Digital health · 2026Article
- Impact of Acute Valve Syndrome on Outcomes of Aortic Valve Replacement for Aortic Stenosis.Journal of the American Heart Association · 2025Article
- The value of evaluating cardiac damage in patients with aortic stenosis: a systematic review and meta-analysis.Echo research and practice · 2025Review
- Prognostic impact of right ventricular dysfunction in patients with severe aortic stenosis treated with trans-catheter aortic valve implantation.Internal and emergency medicine · 2025Article
- Aortic Valve Replacement in Asymptomatic Severe Aortic Stenosis: A Systematic Review and Meta-Analysis.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Review
- Staging Aortic Stenosis Based on Cardiac Damage: A New Tool for Risk Prediction, Clinical Decision-Making, and Trial Design.Structural heart : the journal of the Heart Team · 2025Review
- Longitudinal Outcomes of Left Ventricular Outflow Tract Obstruction in Aortic Stenosis Versus Hypertrophic Obstructive Cardiomyopathy.Medicina (Kaunas, Lithuania) · 2025Article
- Impact of SGLT2-inhibitors on acute kidney injury in diabetic patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI).Cardiovascular diabetology · 2025Observational
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The prognostic value of cardiac damage staging classification based on the extent of extravalvular damage has been proposed in moderate/severe aortic stenosis (AS). Objectives: The purpose of this study was to assess the association of cardiac damage staging with mortality across the spectrum of patients with AS following aortic surgical or transcatheter aortic valve replacement (AVR). Methods: We conducted a pooled meta-analysis of Kaplan-Meier-derived reconstructed time-to-event data from studies published through February 2023. Results: In total, 16 studies (n = 14,499) met our eligibility criteria and included 12,282 patients with symptomatic severe AS and 2,217 patients with asymptomatic severe/moderate AS. For patients with symptomatic severe AS, all-cause mortality was 24.0%, 27.7%, 38.0%, 56.3%, and 57.3% at 5 years in patients with cardiac damage stage 0, 1, 2, 3, and 4, respectively (stage 0 as reference; HR in stage 1: 1.30 [95% CI: 1.03-1.64]; Conclusions: In patients undergoing AVR across the symptomatic and severity spectrum of AS, cardiac damage staging at baseline has important prognostic implications. This pooled meta-analysis in patients undergoing AVR suggests that staging of baseline cardiac damage could be considered for timing and selection of therapy in patients with moderate or severe AS to determine the need for earlier AVR or adjunctive pharmacotherapy to prevent irreversible cardiac damage and improve the long-term prognosis.
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