ArticleJACC. Advances2024
PET/CT Assessment of Flow-Mediated Epicardial Vasodilation in Obesity and Severe Obesity.
Article in JACC. Advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Quantitative and semi-quantitative comparison of myocardial blood flow betweenQuantitative imaging in medicine and surgery · 2026Article
- Prevalence of impaired flow-mediated epicardial vasodilation among different types of coronary flow regulation.The international journal of cardiovascular imaging · 2026Article
- Spinal cord FDG PET uptake in healthy adults: an AI-driven segmentation study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Classical and endogen type of coronary microvascular dysfunction and potential association with cardiovascular events in a cardiometabolic disease population.The international journal of cardiovascular imaging · 2026Article
- Cardiac and renal sympathetic nerve activation in early-stage HFpEF: insights fromThe international journal of cardiovascular imaging · 2026Article
- Concordance-discordance between apolipoprotein B and lipid biomarkers in predicting 20-year atherosclerotic cardiovascular disease risk: The ATTICA study (2002-2022).European journal of clinical investigation · 2025Article
- Differential effects of bariatric surgery on circulating GDF15 and FGF21 levels: Implications for glycemic status and weight loss outcomes.European journal of clinical investigation · 2025Article
- Coronary vasodilator capacity in obesity and morbid obesity - divergent flow responses with left ventricular hypertrophy.International journal of cardiology. Heart & vasculature · 2025Article
- Total-body positron emission tomography: Investigating mechanisms in cardiovascular-kidney-metabolic syndrome.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025Review
- Homogeneous reduction of 15O-water and PET-determined myocardial flow reserve as a reflection of coronary microvascular dysfunction?European heart journal. Cardiovascular Imaging · 2025Article
- Impact of physiological and coronary artery disease risk factors on myocardial perfusion in stress computed tomography myocardial perfusion imaging.Scientific reports · 2025Article
- Functional or structural impairment of flow-mediated epicardial vasodilation may precede coronary microvascular dysfunction.International journal of cardiology. Heart & vasculature · 2025Article
- Coronary Pathophysiology Underlying the Obesity Paradox.JACC. Advances · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Background: It is not known whether the transition from obesity and severe obesity, as 2 different metabolic disease entities, affect flow-mediated and, thus, endothelium-dependent epicardial vasodilation. Objectives: The purpose of this study was to investigate the effect of obesity and severe obesity on flow-mediated epicardial vasomotion with positron emission tomography/computed tomography-determined longitudinal decrease in myocardial blood flow (MBF) from the base-to-apex direction of the left ventricle or gradient. Methods: Results: Compared to NW, left ventricular Δ longitudinal MBF gradient progressively declined in OW and OB (0.04 ± 0.09 mL/g/min vs -0.11 ± 0.14 mL/g/min and -0.15 ± 0.11 mL/g/min; Conclusions: Increased body weight associates with abnormalities in coronary circulatory function that advances from an impairment flow-mediated, epicardial vasodilation in overweight and obesity to coronary microvascular dysfunction in obesity, not observed in severe obesity. The U-turn of flow-mediated epicardial vasomotion outlines obesity and severe obesity to affect epicardial endothelial function differently.
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