ArticleJACC. Advances2024
Nontraditional Risk Markers for Incident Coronary Artery Calcium Among Persons ≥65 Years of Age.
Article in JACC. Advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Impact of Renal Disease Markers on Cardiovascular Disease Risk Prediction When Coronary Calcium Score Is Known.Journal of the American Heart Association · 2026Article
- Association of serum uric acid with incident vascular calcification in patients with type 2 diabetes mellitus: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Association of thoracic aortic calcium with incident cardiovascular disease and all-cause mortality across the spectrum of coronary artery calcium burden.American journal of preventive cardiology · 2025Article
- Beyond the Agatston calcium score: role of calcium density and other calcified plaque markers for cardiovascular disease prediction.Current opinion in cardiology · 2025Review
- Atherosclerotic Cardiovascular Diseases Are Associated With Incident Metastatic and Nonmetastatic Cancer.JACC. CardioOncology · 2024Article
- Coronary artery calcium: The canary in the coal mine.Atherosclerosis · 2024Article
- Physiology and functional significance of the coronary microcirculation: An overview of its implications in health and disease.American heart journal plus : cardiology research and practice · 2024Article
- Coronary Atherosclerosis: Causes, Consequences, and the Passage of Time.JACC. Advances · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The initiation of coronary artery calcium (CAC) is an important physiologic milestone associated with increased cardiovascular disease risk. However, traditional risk factors (RF) do not perform well for predicting incident CAC among the 54 million older U.S. adults. Objectives: The authors sought to assess the association between nontraditional cardiovascular disease RF and incident CAC in older persons. Methods: There were 815 MESA (Multi-Ethnic Study of Atherosclerosis) participants ≥65 years of age who had CAC = 0 at Visit 1 and a follow-up CAC scan. Multivariable adjusted Cox hazards ratios (aHR) and C-statistics were calculated to examine the association of nontraditional RF with incident CAC. Results: The mean age was 70.2 years and 67% were women. The median follow-up time to repeat CAC scan was 3.6 years (IQR: 2.6-9.2 years) and 45% of participants developed incident CAC. Albuminuria (aHR: 1.50, 95% CI: 1.07-2.09), carotid plaque (aHR: 1.32, 95% CI: 1.04-1.66), and thoracic aortic calcification (TAC) (aHR: 1.38, 95% CI: 1.10-1.75) were significantly associated with incident CAC, while higher levels of nontraditional RF including apolipoprotein-B, lipoprotein(a), high-sensitivity troponin T, and N-terminal pro-brain natriuretic peptide were not. When added to demographics, albuminuria, carotid plaque, and TAC provided a greater C-statistic improvement (+0.047, Conclusions: Among nontraditional RF and measures of subclinical atherosclerosis, only albuminuria, carotid plaque, and TAC were significantly associated with incident CAC in persons ≥65 years of age. Identification of albuminuria or extracoronary atherosclerosis may help guide the timing of repeat CAC scoring in older persons with baseline CAC = 0.
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