Evidence map›Paper›PMID 38939123›Full record

ArticleJournal of open source software2023

HNN-core: A Python software for cellular and circuit-level interpretation of human MEG/EEG.

Mainak Jas, Ryan Thorpe, Nicholas Tolley, Christopher Bailey, Steven Brandt, Blake Caldwell, Huzi Cheng, Dylan Daniels, Carolina Fernandez Pujol, Mostafa Khalil and 12 more

Abstract read
In one paragraph

Article in Journal of open source software, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Deviance detection via competitive inhibition between local neocortical ensembles.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Mainak JasAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-3199-9027
Ryan ThorpeDepartment of Neuroscience, Brown University, Providence, RI, USA.ORCID 0000-0003-2491-8599
Nicholas TolleyDepartment of Neuroscience, Brown University, Providence, RI, USA.ORCID 0000-0003-0358-0074
Christopher BaileyDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0003-3318-3344
Steven BrandtDepartment of Neuroscience, Brown University, Providence, RI, USA.
Blake CaldwellBassett Medical Center, Cooperstown, NY, USA.ORCID 0000-0002-6882-6998
Huzi ChengDepartment of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, IN, USA.
Dylan DanielsRobert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, RI, USA.ORCID 0009-0008-1958-353X
Carolina Fernandez PujolDepartment of Biomedical Engineering, University of Miami, Coral Gables, FL, USA.ORCID 0009-0003-0611-1270
Mostafa KhalilDepartment of Psychiatry and Behavioral Health, Penn State Milton S. Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.
Samika KanekarWarren Alpert Medical, Brown University, Providence, RI.ORCID 0000-0002-6111-4461
Carmen KohlRobert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, RI, USA.ORCID 0000-0001-7585-595X
Orsolya KolozsváriDepartment of Psychology, University of Jyväskylä, Jyväskylä, Finland.ORCID 0000-0002-1619-6314
Kaisu LankinenAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-2210-2385
Kenneth LoiRobert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, RI, USA.
Sam NeymotinCenter for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.ORCID 0000-0003-3646-5195
Rajat PartaniDepartment of Computer Science and Engineering, National Institute of Technology Karnataka, Karnataka, India.ORCID 0000-0002-6863-7046
Mattan PelahRobert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, RI, USA.
Alex RockhillDepartment of Human Physiology, University of Oregon, Eugene, OR, USA.ORCID 0000-0003-3868-7453
Mohamed SherifDepartment of Psychiatry and Human Behavior, Brown University, Providence, RI, USA.ORCID 0000-0002-8951-1645
Matti HamalainenDepartment of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland.ORCID 0000-0001-6841-112X
Stephanie JonesDepartment of Neuroscience, Brown University, Providence, RI, USA.ORCID 0000-0001-6760-5301

Funding

Scalable Software for Distributed Processing and Visualization of Multi-Site MEG/EEG DatasetsR01NS104585 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MATTI HAMALAINEN · 2018 to 2026
$4.3M
Dissemination of the Human Neocortical Neurosolver (HNN) software for circuit level interpretation of human MEG/EEGU24NS129945 · NINDS · BROWN UNIVERSITY · PI STEPHANIE Ruggiano JONES · 2023 to 2026
$2.8M
Training Program for Interactionist Cognitive Neuroscience (ICoN)T32MH115895 · NIMH · BROWN UNIVERSITY · PI MICHAEL J. FRANK, STEPHANIE Ruggiano JONES · 2019 to 2026
$1.8M
Human Neocortical NeurosolverR01EB022889 · NIBIB · BROWN UNIVERSITY · PI HAMALAINEN, MATTI, HINES, MICHAEL L · 2016 to 2018
$1.7M
Advancing the Research Careers of Women and PEERs in Brain ScienceR25NS124530 · NINDS · BROWN UNIVERSITY · PI CARLOS D AIZENMAN, Diane Lipscombe · 2022 to 2026
$1.3M
Secondary analysis of resting state MEG data using the Human Neocortical Neurosolver software tool for cellular and circuit-level interpretationRF1MH130415 · NIMH · BROWN UNIVERSITY · PI JONES, STEPHANIE RUGGIANO · 2022 to 2022
$1.2M
CRCNS: US-Spain Research Proposal: Interpreting MEG Biomarkers of Alzheimer's Progression with Human Neocortical NeurosolverR01AG076227 · NIA · BROWN UNIVERSITY · PI JONES, STEPHANIE RUGGIANO · 2021 to 2023
$717k
NIA NIH HHS R01 AG076227NIBIB NIH HHS R01 EB022889NIMH NIH HHS RF1 MH130415NIMH NIH HHS T32 MH115895NINDS NIH HHS R01 NS104585NINDS NIH HHS R25 NS124530NINDS NIH HHS U24 NS129945
6 · The paper itself

Abstract

HNN-core is a library for circuit and cellular level interpretation of non-invasive human magneto-/electro-encephalography (MEG/EEG) data. It is based on the Human Neocortical Neurosolver (HNN) software (Neymotin et al., 2020), a modeling tool designed to simulate multiscale neural mechanisms generating current dipoles in a localized patch of neocortex. HNN's foundation is a biophysically detailed neural network representing a canonical neocortical column containing populations of pyramidal and inhibitory neurons together with layer-specific exogenous synaptic drive (Figure 1 left). In addition to simulating network-level interactions, HNN produces the intracellular currents in the long apical dendrites of pyramidal cells across the cortical layers known to be responsible for macroscopic current dipole generation.

Identifiers

PMID38939123
PMCPMC11210709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.