Evidence map›Paper›PMID 38939101›Full record

ArticleDementia and geriatric cognitive disorders extra

Depressive Symptoms Are Not Associated with Predementia Cerebrospinal Fluid Amyloid Pathology.

Cecilia Magdalena Eriksson, Bjørn-Eivind Kirsebom, Ragna Espenes, Nikias Siafarikas, Knut Waterloo, Arvid Rongve, Per Selnes, Dag Aarsland, Tormod Fladby, Erik Hessen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cecilia Magdalena ErikssonDepartment of Geriatric Psychiatry, Akershus University Hospital, Nordbyhagen, Norway.
Bjørn-Eivind KirsebomDepartment of Neurology, University Hospital of North Norway, Tromsø, Norway.
Ragna EspenesDepartment of Neurology, University Hospital of North Norway, Tromsø, Norway.
Nikias SiafarikasDepartment of Geriatric Psychiatry, Akershus University Hospital, Nordbyhagen, Norway.
Knut WaterlooDepartment of Neurology, University Hospital of North Norway, Tromsø, Norway.
Arvid RongveDepartment of Research and Innovation, Helse Fonna, Haugesund, Norway.
Per SelnesDepartment of Neurology, Akershus University Hospital, Nordbyhagen, Norway.
Dag AarslandDepartment of Neurology, Akershus University Hospital, Nordbyhagen, Norway.
Tormod FladbyDepartment of Neurology, Akershus University Hospital, Nordbyhagen, Norway.
Erik HessenInstitute of Psychology, University of Oslo, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Depressive symptoms are associated with Alzheimer's disease (AD), but their neurobiological and neuropsychological correlates remain poorly understood. We investigate if depressive symptoms are associated with amyloid (Aβ) pathology and cognition in predementia AD. Methods: We included subjective cognitive decline (SCD, Results: Only the Aβ negative MCI group (MCI-Aβ-) was associated with depressive symptoms (odds ratio [OR] = 2.65, Conclusion: Our results suggest that depressive symptoms in MCI are neither associated with Aβ pathology, nor AD-associated memory impairment. However, memory impairment in non-AD MCI may relate to depressive symptoms.

Indexed as

Alzheimer’s diseaseAmyloid Aβ42/40 ratioCerebrospinal fluid biomarkersDepressionMild cognitive impairmentSubjective cognitive decline

Identifiers

PMID38939101
PMCPMC11208998

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.