ArticleJACC. Advances2022
A Simulation Study of the Effects of Number and Location of MitraClips on Mitral Regurgitation.
Article in JACC. Advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Simulation of Transcatheter Therapies for Atrioventricular Valve Regurgitation in an Open-Source Finite Element Simulation Framework.Annals of biomedical engineering · 2026Article
- Leaflet Lengths and Commissural Dimensions as the Primary Determinants of Orifice Area in Mitral Regurgitation: A Sobol Sensitivity Analysis.Bioengineering (Basel, Switzerland) · 2026Article
- A nationwide analysis of resource utilization and safety in patients undergoing mitral transcatheter edge-to-edge repair.International journal of cardiology. Heart & vasculature · 2025Article
- Simulation for Procedural Planning and Intracardiac Echo for Enhancing Precision in Cardiac Interventions With a Focus on Left Atrial Appendage Closure.Structural heart : the journal of the Heart Team · 2025Review
- Simulation for Procedural Planning and Intracardiac Echo for Enhancing Precision in Cardiac Interventions With a Focus on Left Atrial Appendage Closure.Structural heart : the journal of the Heart Team · 2025Review
- Harnessing Artificial Intelligence for Innovation in Interventional Cardiovascular Care.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Review
- Towards standardizing mitral transcatheter edge-to-edge repair with deep-learning algorithm: a comprehensive multi-model strategy.Frontiers in network physiology · 2025Article
- Looking towards the future: patient-specific computational modeling to optimize outcomes for transcatheter mitral valve repair.Frontiers in cardiovascular medicine · 2023Review
- Can Machines Find the Sweet Spot in End-Stage Heart Failure?JACC. Advances · 2022Article
- Computer Modeling of Valve Disease: A New Old Technique to Understand and Predict Outcomes.JACC. Advances · 2022Article
- Effect of transcatheter edge-to-edge repair device position on diastolic hemodynamic parameters: An echocardiography-based simulation study.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Background: MitraClip (MC) is a device that is implanted on the mitral valve (MV) percutaneously to treat severe mitral regurgitation (MR). It is common practice to place the MCs at the site of the most significant MR jets identified by echocardiography. Objectives: We used computational modeling to examine changes in MR after MC placement. Methods: Echocardiographic images from 29 patients with MR were analyzed to reconstruct geometries for finite element simulations and created fluid structure interaction models of the MV with deformable hyperelastic material, the left ventricle as the surrounding geometry, and blood flow. Blood flow was modelled with smoothed particle hydrodynamics. The number of blood particles on the atrial side of MV was used to estimate MR. MC placement was based on the MR jets (jet-based strategy using primary and secondary jets) and simulation models using various MCs locations. Results: Computational modelling was able to quantitate reductions in MR after MC placement. Reduction in MR was related to the number of MCs used: 42% reduction with 1 MC, 62% with 2 MCs, and 88% with 3 MCs. Using 2 MCs did not always result in an MR reduction greater than with a single MC. In 31% (9 of 29) of patients, the jet-based strategy did not lead to maximum MR reduction. The majority of patients (89%) who did not have maximal MR reduction with the MC placement using the jet-based strategy, had wide jets, and/or had multiple jets. Conclusions: Subject-specific simulation models may be helpful to identify optimal locations for MC placement in patients with MR.
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