Evidence map›Paper›PMID 38939045›Full record

ArticleAnnals of case reports2024

Spontaneous Regression Accompanied by Concomitant Immune Alterations in a Patient with Chronic Lymphocytic Leukemia.

Gonzalo Blanco, Edward Morris, Jodie L Morris, Hayley L Letson, Suvarna Susheel, Anna Puiggros, Blanca Espinet, Nicholas Chiorazzi, Geoffrey P Dobson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gonzalo BlancoKarches Center for Oncology Research, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Edward MorrisDepartment of Clinical Hematology, Icon Cancer Care, Hyde Park, QLD, Australia.
Jodie L MorrisHeart and Trauma Research Laboratory, College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.
Hayley L LetsonHeart and Trauma Research Laboratory, College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.
Suvarna SusheelJCU Health, Clinical Practice Bld, Douglas, QLD, Australia.
Anna PuiggrosHospital del Mar Medical Research Institute (IMIM), Hospital del Mar, Barcelona, 08003, Spain.
Blanca EspinetHospital del Mar Medical Research Institute (IMIM), Hospital del Mar, Barcelona, 08003, Spain.
Nicholas ChiorazziKarches Center for Oncology Research, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Geoffrey P DobsonHeart and Trauma Research Laboratory, College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.

Funding

Th17 generation, action and therapeutic relevance in chronic lymphocytic leukemiaR01CA238523 · NCI · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CHIORAZZI, NICHOLAS, SHERRY, BARBARA A · 2020 to 2024
$2.7M
NCI NIH HHS R01 CA238523
6 · The paper itself

Abstract

Spontaneous regression (SR) of chronic lymphocytic leukemia (CLL) is a rare event (0.2% - 1%). Some advances have been made in understanding the tumor genetic characteristics of such patients, although the immunological mechanisms leading to SR remain unclear. We describe a series of immunological events related to regression dynamics, allowing the identification of a SR phase (associated with >99% reduction of CLL cells in peripheral blood and adenopathy resolution in less than one year, concurrently with a nine-fold increase in monocyte counts, high B2M and the appearance of an oligoclonal serum IgG band), followed by a persistent regression (PR) phase that was maintained for ≥17 months. Our observations highlight a role of monocytes and B2M in SR, potentially related to immune activation. The oligoclonal IgG band detected during SR was maintained in PR, suggesting either a change in the ability of malignant cells (IgM

Indexed as

Immunoglobulin G (IgG)MonocytesPersistent Regression (PR)Spontaneous Regression (SR)β−2 Microglobulin (B2M)

Identifiers

PMID38939045
PMCPMC11210401

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.