ReviewJACC. Advances2023
Radiation-Induced Aortic Stenosis: An Update on Treatment Modalities.
Review in JACC. Advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Commando procedure in cardiac surgery: a narrative review.General thoracic and cardiovascular surgery · 2025Pooled it
- Clinical outcomes of transcatheter aortic valve replacement in patients with radiation-induced aortic stenosis: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Calcific Aortopathy in Response to Aging and Injury.Circulation · 2026Review
- Review
- Radiation-Induced Valvular Heart Disease: A Narrative Review of Epidemiology, Diagnosis and Management.Journal of cardiovascular development and disease · 2025Review
- Echocardiographic monitoring in cancer therapy: clinical guidance for cardiologists and oncologists.Heart failure reviews · 2025Review
- Treating a Childhood Cancer Survivor With Severe Aortic and Mitral Insufficiency Using TAVR and TMVR.JACC. Case reports · 2025Article
- Thoracobifemoral bypass for radiation-induced paravisceral aortic stenosis.Journal of vascular surgery cases and innovative techniques · 2025Article
- Radiation-Induced Cardiac Remodeling: Mechanisms and Therapeutic Approaches.Cardiovascular toxicology · 2025Review
- Integration and Potential Applications of Cardiovascular Computed Tomography in Cardio-Oncology.Current cardiology reports · 2025Review
- Porcelain Aorta and Radiation-Induced Mitral Annular Calcification Are Not Contraindications to Surgery.JACC. Case reports · 2025Article
- Surgical coronary angioplasty of both coronary ostia after chest radiotherapy. Is it good alternative to conventional coronary bypass surgery?Perfusion · 2025Article
- Hybrid Approach to Post-Radiation Valve Disease: Robotic Mitral Valve Replacement Alongside Transcatheter Aortic Valve Replacement.JACC. Case reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adverse effects of radiation therapy for cancer are well described and can include a wide array of cardiac complications. Radiation-induced aortic stenosis (AS) is an increasingly recognized entity that poses particular therapeutic challenges. Several retrospective studies comparing the outcomes after transcatheter aortic valve replacement (TAVR) vs those after surgical aortic valve replacement patients with radiation-induced AS have found a trend toward decreased mortality and fewer major complications with TAVR. Surgical aortic valve replacement is associated with increased mortality in patients with radiation-induced AS compared with patients without a history of prior radiation. TAVR has been shown to be a safe and effective alternative in patients with radiation-induced AS, with safety similar to that for patients who have not received prior radiation. However, rare and unexpected complications may occur after TAVR from the deleterious effects of radiation on mediastinal structures. More studies are needed to identify the optimal way of managing patients with radiation-induced AS, and algorithms are needed for planning these complex interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.