Evidence map›Paper›PMID 38938981›Full record

ArticleFrontiers in bioengineering and biotechnology2024

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery.

Hairong Mao, Jianfeng Zhou, Liang Yan, Shuping Zhang, Deng-Guang Yu

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Review
  6. Versatility of electrospun Janus wound dressings.Nanomedicine (London, England) · 2025
    Review
  7. Review
  8. Electrospun nanofibers and their application as sensors for healthcare.Frontiers in bioengineering and biotechnology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Hairong MaoCollege of Chemistry and Chemical Engineering, Zhengzhou Normal University, Zhengzhou, Henan, China.
Jianfeng ZhouSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China.
Liang YanSchool of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Shuping ZhangSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China.
Deng-Guang YuSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combination therapy with oral administration of several active ingredients is a popular clinical treatment for cancer. However, the traditional method has poor convenience, less safety, and low efficiency for patients. The combination of traditional pharmaceutical techniques and advanced material conversion methods can provide new solutions to this issue. In this research, a new kind of hybrid film was created via coaxial electrospraying, followed by a casting process. The films were composed of Reglan and 5-fluorouracil (5-FU)-loaded cellulose acetate (CA) core-shell particles in a polyvinylpyrrolidone (PVP) film matrix. Microscopic observations of these films demonstrated a solid cross section loaded with core-shell particles. X-ray diffraction and Fourier-transform infrared tests verified that the Reglan and 5-FU loaded in the films showed amorphous states and fine compatibilities with the polymeric matrices, i.e., PVP and CA, respectively.

Indexed as

asynchronous dual-drug deliverycastingcoaxial electrosprayingcolon cancerhybrid filmssynergistic therapytumor-targeted therapy

Identifiers

PMID38938981
PMCPMC11208691

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.