Evidence map›Paper›PMID 38938794›Full record

ArticleJACS Au2024

Integrating Au Catalysis and Engineered Amine Dehydrogenase for the Chemoenzymatic Synthesis of Chiral Aliphatic Amines.

Jianqiao Liu, Jing Bai, Yunting Liu, Liya Zhou, Ying He, Li Ma, Guanhua Liu, Jing Gao, Yanjun Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jianqiao LiuSchool of Chemical Engineering and Technology, Hebei University of Technology, 5340 Xiping Rd., Tianjin 300130, China.
Jing BaiCollege of Food Science and Biology, Hebei University of Science & Technology, 26 Yuxiang Street, Yuhua District, Shijiazhuang 050018, China.
Yunting LiuSchool of Chemical Engineering and Technology, Hebei University of Technology, 5340 Xiping Rd., Tianjin 300130, China.ORCID https://orcid.org/0000-0003-3799-0362
Liya ZhouSchool of Chemical Engineering and Technology, Hebei University of Technology, 5340 Xiping Rd., Tianjin 300130, China.
Ying HeSchool of Chemical Engineering and Technology, Hebei University of Technology, 5340 Xiping Rd., Tianjin 300130, China.ORCID https://orcid.org/0000-0002-8857-3545
Li MaSchool of Chemical Engineering and Technology, Hebei University of Technology, 5340 Xiping Rd., Tianjin 300130, China.
Guanhua LiuSchool of Chemical Engineering and Technology, Hebei University of Technology, 5340 Xiping Rd., Tianjin 300130, China.ORCID https://orcid.org/0000-0002-0824-9738
Jing GaoSchool of Chemical Engineering and Technology, Hebei University of Technology, 5340 Xiping Rd., Tianjin 300130, China.
Yanjun JiangSchool of Chemical Engineering and Technology, Hebei University of Technology, 5340 Xiping Rd., Tianjin 300130, China.ORCID https://orcid.org/0000-0003-1470-2102

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Direct synthesis of aliphatic amines from alkynes is highly desirable due to its atom economy and high stereoselectivity but still challenging, especially for the long-chain members. Here, a combination of Au-catalyzed alkyne hydration and amine dehydrogenase-catalyzed (AmDH) reductive amination was constructed, enabling sequential conversion of alkynes into chiral amines in aqueous solutions, particularly for the synthesis of long-chain aliphatic amines on a large scale. The production of chiral aliphatic amines with more than 6 carbons reached 36-60 g/L. A suitable biocatalyst [

Identifiers

PMID38938794
PMCPMC11200242

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