ArticleJACC. Advances2023
Pathological Analysis of Medial and Intimal Calcification in Lower Extremity Artery Disease: Impact of Hemodialysis.
Article in JACC. Advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Comparative analysis of biologic drug effects and distal particulate embolization among three drug-coated balloons: a histological and biological study in a rabbit model.Cardiovascular intervention and therapeutics · 2026Article
- Intraprocedural Hemodynamics During Concomitant Rheocarna Therapy and Maintenance Hemodialysis: Effects of Dialyzer Membrane Type and Circuit Sequence.Journal of clinical apheresis · 2026Article
- Pathology-validated prevalence and clinical characteristics of coronary medial arterial calcification.European heart journal open · 2026Article
- Pathological evaluation of IVL-enabled modification and crossing in calcified chronic total occlusions.Cardiovascular intervention and therapeutics · 2026Article
- Chronic Limb-Threatening Ischemia in Patients Undergoing Hemodialysis: Epidemiology, Risk Factors, and Outcomes.Journal of atherosclerosis and thrombosis · 2026Article
- Five-year histological evaluation of paclitaxel-eluting stent for an infrapopliteal lesion: a case report.European heart journal. Case reports · 2026Article
- Vascular Calcification in Chronic Kidney Disease and Hemodialysis: Pathophysiological Mechanisms and Emerging Biomarkers.Medicina (Kaunas, Lithuania) · 2025Review
- Femoropopliteal arterial bone formation.European heart journal. Case reports · 2025Article
- Ex vivo micro-computed tomography analysis of the fracking technique for a nodular calcification in the common femoral artery.Cardiovascular intervention and therapeutics · 2025Article
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Authors and funding
20 authors.
Funding
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Abstract
Background: The prevalence and degree of lower extremity artery disease in hemodialysis (HD) patients is higher than in the general population. However, the pathological features have not yet been evaluated. Objectives: The aim of the study was: 1) to compare lesion characteristics of lower extremity artery disease in HD vs non-HD patients; and 2) to determine factors associated with severe medial calcification. Methods: Seventy-seven lower limb arteries were assessed from 36 patients (median age 77 years; 23 men; 21 HD and 15 non-HD) who underwent autopsy or lower limb amputation. Arteries were serially cut at 3- to 4-mm intervals creating 2,319 histological sections. Morphometric analysis and calcification measurements were performed using ZEN software. Calcification with a circumferential angle (arc) ≥180° was defined as severe calcification. Multivariable logistic regression was used to identify risk factors for severe medial calcification. Results: The degree of the medial calcification arc was significantly higher in the HD group compared to the non-HD group ( Conclusions: Hemodialysis patients demonstrated a higher degree of medial and intimal calcification compared with non-HD patients. The difference was more prominent in the medial calcification of below-the-knee lesions.
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