Reproductive Factors Linked With Myocardial Fibrosis: MESA (Multi-Ethnic Study of Atherosclerosis).

Omar Chehab, Ralph Zeitoun, Vinithra Varadarajan, Colin Wu, David A Bluemke, Wendy S Post, Erin D Michos, Joao A C Lima

Abstract read

In one paragraph

Article in JACC. Advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Complex Connections: Myocardial Fibrosis, Reproductive Factors, and Heart Failure.JACC. Advances · 2023
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Omar ChehabDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Ralph ZeitounDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Vinithra VaradarajanDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Colin WuOffice of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

David A BluemkeDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Wendy S PostDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Erin D MichosDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Joao A C LimaDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recent evidence has shown that reproductive factors are associated with an increased risk of heart failure with preserved ejection fraction in women. However, the pathogenic pathways underlying this relationship are unclear. Subclinical myocardial fibrosis has been found to be a common pathway in a large proportion of patients with heart failure with preserved ejection fraction. Objectives: This study examined the relationship between vital reproductive factors (parity, pregnancy, age at menopause, and use of hormone replacement therapy [HRT]) with interstitial myocardial fibrosis (IMF) and myocardial scar measured by cardiac magnetic resonance imaging (CMR) T1 mapping and late gadolinium enhancement, respectively. Methods: There were 596 female participants (mean age 67 ± 8 years) enrolled in MESA (Multi-Ethnic Study of Atherosclerosis) who had complete parity data and underwent CMR. Parity was categorized as 0 live births, 1 to 2, 3 to 4, and ≥5 live births. Multivariable regression models were constructed to assess the associations of parity status, history of null gravidity, age at menopause and HRT with CMR obtained measures of IMF (extracellular volume [ECV], native-T1 time) and myocardial scar. Results: Women with a history of nulliparity had greater ECV% (β = 0.95 ± 0.28, Conclusions: In a multiethnic cohort, women with a history of nulliparity or null gravidity had greater IMF defined by CMR, while those who used HRT were less likely to have myocardial scar.

Indexed as

hormone replacement therapymagnetic resonance imagingmenopausemyocardial fibrosispregnancywomen

Identifiers

PMID38938498

DOI10.1016/j.jacadv.2023.100703

PMCPMC11198357

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.