Evidence map›Paper›PMID 38938489›Full record

ArticleJACC. Advances2023

COVID-19-Related Thrombotic and Bleeding Events in Adults With Congenital Heart Disease.

Flavia Fusco, Richard A Krasuski, Soraya Sadeghi, Marlon S Rosenbaum, Matthew J Lewis, Matthew R Carazo, Fred H Rodriguez, Dan G Halpern, Jodi L Feinberg, Francisca A Galilea and 60 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Daily issues in the life of adults with congenital heart disease: new insights from EURO-ACHD Congress 2025.European heart journal supplements : journal of the European Society of Cardiology · 2026
    Article
  2. Article
  3. Article
  4. Dynamic Coagulation Function Changes in COVID-19 Survivors With Coronary Artery Disease.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

70 authors.

Flavia FuscoAdult Congenital Heart Disease Unit, Monaldi Hospital, Naples, Italy.
Richard A KrasuskiDepartment of Cardiovascular Medicine, Duke University Health System in Durham, Durham, North Carolina, USA.
Soraya SadeghiAhmanson/UCLA Adult Congenital Heart Center, Los Angeles, California, USA.
Marlon S RosenbaumDivision of Cardiology, Columbia University Medical Center, New York, New York, USA.
Matthew J LewisDivision of Cardiology, Columbia University Medical Center, New York, New York, USA.
Matthew R CarazoDivision of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.
Fred H RodriguezDivision of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.
Dan G HalpernDivision of Cardiology, New York University Langone Health, New York, New York, USA.
Jodi L FeinbergDivision of Cardiology, New York University Langone Health, New York, New York, USA.
Francisca A GalileaInstituto Nacional del Tórax - Pontificia Universidad Católica de Chile, Santiago, Chile.
Fernando BaraonaInstituto Nacional del Tórax - Pontificia Universidad Católica de Chile, Santiago, Chile.
Ari M CedarsDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jong M KoDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Prashob PorayetteDivision of Cardiology, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.
Jennifer R MaldonadoDivision of Cardiology, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.
Alexandra A FrogoudakiSecond Cardiology Department, ATTIKON University Hospital, Athens, Greece.
Amiram NirPediatric Cardiology and Adult Congenital Heart Disease Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
Anisa ChaudhryPenn State Hershey Heart and Vascular Institute, State College, Pennsylvania, USA.
Anitha S JohnDivision of Cardiology, Children's National Hospital, Washington, District of Columbia, USA.
Arsha KarbassiMcMaster University, Hamilton, Ontario, Canada.
Javier GanameMcMaster University, Hamilton, Ontario, Canada.
Arvind HoskoppalUPMC Adult Congenital Heart Disease Program, Pittsburgh, Pennsylvania, USA.
Benjamin P FrischhertzDivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Benjamin HendricksonLe Bonheur Heart Institute, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Carla P Rodriguez-MonserrateDepartment of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.
Christopher R BrodaDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Daniel ToblerDivision of Cardiology, University Hospital of Basel, Basel, Switzerland.
David GreggDivision of Cardiology, Medical University of South Carolina, Charleston, South Carolina, USA.
Efrén Martinez-QuintanaCardiology Service, Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria, Spain.
Elizabeth YeungColorado's Adult and Teen Congenital Heart Program, Colorado University School of Medicine, Aurora, Colorado, USA.
Eric V KriegerDivision of Cardiology, University of Washington School of Medicine, Seattle, Washington, USA.
Francisco J Ruperti-RepiladoDivision of Cardiology, University Hospital Geneva, Geneva, Switzerland.
George GiannakoulasCardiology Department, AHEPA University Hospital, Thessaloniki, Greece.
George K LuiDivision of Cardiovascular Medicine and Pediatric Cardiology, Stanford University School of Medicine, Stanford, California, USA.
Georges EphremKrannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Harsimran S SinghDepartment of Medicine & Pediatrics, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA.
Almeneisi HasanThe Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Heather L BartlettDepartment of Pediatrics and Medicine, University of Wisconsin, Madison, Wisconsin, USA.
Ian LindsayDivision of Pediatric Cardiology, University of Utah, Salt Lake City, Utah, USA.
Jasmine GrewalSt. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Jeremy NicolarsenDepartment of Pediatric and Adult Cardiology, Providence Adult and Teen Congenital Heart Program, Spokane, Washington, USA.
John J AraujoDepartment of Pediatric and Adult Congenital Heart Disease, Somer Incare Cardiovascular Center, Rionegro, Colombia.
Jonathan W CramerDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Judith BouchardyDepartment of Cardiology and Cardiac Surgery, University Hospital Lausanne, Lausanne, Switzerland.
Khalid Al NajashiPediatric Cardiology Department, Prince Sultan Cardiac Center, Riyadh, Saudi Arabia.
Kristi RyanAdult Congenital Heart Program, OSF Healthcare Children's Hospital of Illinois, Peoria, Illinois, USA.
Laith AlshawabkehDepartment of Cardiovascular Medicine, University of California-San Diego, La Jolla, California, USA.
Lauren AndradeDivision of Cardiology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Magalie LadouceurAdult Congenital Heart Disease Unit, Hôpital Européen Georges Pompidou, AP-HP, Université de Paris Cité, Paris, France.
Markus SchwerzmannCenter for Congenital Heart Disease, University Hospital Inselspital, Bern, Switzerland.
Matthias GreutmannDepartment of Cardiology, University of Zurich, Zurich, Switzerland.
Pablo MerásCardiology Department, University Hospital La Paz, Madrid, Spain.
Paolo FerreroCardiovascular Department, ASST Papa Giovanni XXIII, University of Milano, Bergamo, Italy.
Payam DehghaniPrairie Vascular Research Network, University of Saskatchewan, Regina, Saskatchewan, Canada.
Poyee P TungDivision of Adult Congenital Heart Disease, University of Texas at Houston, Houston, Texas, USA.
Rocio Garcia-OrtaCardiology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Rose TompkinsThe Geurin Family Congenital Heart Program, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Salwa M GendiAdult Congenital Heart Disease Program, West Virginia University, Morgantown, West Virginia, USA.
Scott CohenAdult Congenital Heart Disease Program, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Scott E KlewerDivision of Cardiology, University of Arizona, Tucson, Arizona, USA.
Sebastien HascoetDepartment of Pediatric Cardiology and Congenital Heart Disease, Hôpital Marie Lannelongue, Le Plessis Robinson, France.
Shailendra UpadhyayDivision of Pediatric Cardiology, Connecticut Children's Medical Center, Hartford, Connecticut, USA.
Stacy D FisherDepartment of Medicine and Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Stephen CookAdult Congenital Heart Center, Helen DeVos Children's Hospital, Grand Rapids, Michigan, USA.
Timothy B CottsDepartment of Medicine and Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Adrienne H KovacsKnight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Jamil A AboulhosnAhmanson/UCLA Adult Congenital Heart Center, Los Angeles, California, USA.
Giancarlo ScognamiglioAdult Congenital Heart Disease Unit, Monaldi Hospital, Naples, Italy.
Craig S BrobergKnight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Berardo SarubbiAdult Congenital Heart Disease Unit, Monaldi Hospital, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Altered coagulation is a striking feature of COVID-19. Adult patients with congenital heart disease (ACHD) are prone to thromboembolic (TE) and bleeding complications. Objectives: The purpose of this study was to investigate the prevalence and risk factors for COVID-19 TE/bleeding complications in ACHD patients. Methods: COVID-19-positive ACHD patients were included between May 2020 and November 2021. TE events included ischemic cerebrovascular accident, systemic and pulmonary embolism, deep venous thrombosis, myocardial infarction, and intracardiac thrombosis. Major bleeding included cases with hemoglobin drop >2 g/dl, involvement of critical sites, or fatal bleeding. Severe infection was defined as need for intensive care unit, endotracheal intubation, renal replacement therapy, extracorporeal membrane oxygenation, or death. Patients with TE/bleeding were compared to those without events. Factors associated with TE/bleeding were determined using logistic regression. Results: Of 1,988 patients (age 32 [IQR: 25-42] years, 47% male, 59 ACHD centers), 30 (1.5%) had significant TE/bleeding: 12 TE events, 12 major bleeds, and 6 with both TE and bleeding. Patients with TE/bleeding had higher in-hospital mortality compared to the remainder cohort (33% vs 1.7%; Conclusions: ACHD patients with TE/bleeding during COVID-19 infection have a higher in-hospital mortality from the illness. Risk of coagulation disorders is related to severe COVID-19, cardiac injury during infection, and use of anticoagulants.

Indexed as

adult congenital heart diseasebleedingCOVID-19thrombosis

Identifiers

PMID38938489
PMCPMC11198511

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