Evidence map›Paper›PMID 38938446›Full record

ArticleJournal of extracellular biology2023

MicroRNA profiling of low concentration extracellular vesicle RNA utilizing NanoString nCounter technology.

Rachel E Crossland, Anna Albiero, Clara Sanjurjo-Rodríguez, Monica Reis, Anastasia Resteu, Amy E Anderson, Anne M Dickinson, Arthur G Pratt, Mark Birch, Andrew W McCaskie and 2 more

Erratum issuedAbstract read
In one paragraph

Article in Journal of extracellular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Extracellular RNAs as Messengers and Early Biomarkers in Neurodegeneration.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
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  12. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Rachel E CrosslandTranslational and Clinical Research Institute, Faculty of Medical Sciences Newcastle University Newcastle upon Tyne UK.ORCID https://orcid.org/0000-0001-6138-160X
Anna AlbieroDivision of Trauma and Orthopaedic Surgery, Department of Surgery University of Cambridge Addenbrooke's Hospital Cambridge UK.ORCID https://orcid.org/0000-0003-3118-5004
Clara Sanjurjo-RodríguezTranslational and Clinical Research Institute, Faculty of Medical Sciences Newcastle University Newcastle upon Tyne UK.ORCID https://orcid.org/0000-0003-2702-7804
Monica ReisTranslational and Clinical Research Institute, Faculty of Medical Sciences Newcastle University Newcastle upon Tyne UK.ORCID https://orcid.org/0000-0002-2534-4964
Anastasia ResteuTranslational and Clinical Research Institute, Faculty of Medical Sciences Newcastle University Newcastle upon Tyne UK.ORCID https://orcid.org/0000-0002-3783-8806
Amy E AndersonTranslational and Clinical Research Institute, Faculty of Medical Sciences Newcastle University Newcastle upon Tyne UK.ORCID https://orcid.org/0000-0003-0532-623X
Anne M DickinsonTranslational and Clinical Research Institute, Faculty of Medical Sciences Newcastle University Newcastle upon Tyne UK.ORCID https://orcid.org/0000-0002-7356-7636
Arthur G PrattTranslational and Clinical Research Institute, Faculty of Medical Sciences Newcastle University Newcastle upon Tyne UK.ORCID https://orcid.org/0000-0002-9909-8209
Mark BirchDivision of Trauma and Orthopaedic Surgery, Department of Surgery University of Cambridge Addenbrooke's Hospital Cambridge UK.
Andrew W McCaskieDivision of Trauma and Orthopaedic Surgery, Department of Surgery University of Cambridge Addenbrooke's Hospital Cambridge UK.ORCID https://orcid.org/0000-0001-6476-0832
Elena JonesLeeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds Leeds UK.ORCID https://orcid.org/0000-0001-9365-2283
Xiao-Nong WangTranslational and Clinical Research Institute, Faculty of Medical Sciences Newcastle University Newcastle upon Tyne UK.ORCID https://orcid.org/0000-0003-1282-8799

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EV) and the microRNAs that they contain are increasingly recognised as a rich source of informative biomarkers, reflecting pathological processes and fundamental biological pathways and responses. Their presence in biofluids makes them particularly attractive for biomarker identification. However, a frequent caveat in relation to clinical studies is low abundance of EV RNA content. In this study, we used NanoString nCounter technology to assess the microRNA profiles of

Indexed as

extracellular vesiclemicroRNANanoStringprofiling

Identifiers

PMID38938446
PMCPMC11080777

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.