Evidence map›Paper›PMID 38938362›Full record

ArticleJACC. Advances2023

Cardiovascular Outcomes in Acute Coronary Syndrome and Malnutrition: A Meta-Analysis of Nutritional Assessment Tools.

Angeline Rx Lai, Manish Warrier, Ethel Zx Ng, Chaoxing Lin, Yip Han Chin, Gwyneth Kong, Vickram V Anand, Ethan Cz Lee, Haoxing Lai, Hung Wei Ng and 12 more

Abstract read
In one paragraph

Article in JACC. Advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Sex differences in survival following acute coronary syndrome with and without standard modifiable risk factors.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Angeline Rx LaiYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Manish WarrierYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Ethel Zx NgYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Chaoxing LinYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Yip Han ChinYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Gwyneth KongYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Vickram V AnandLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Ethan Cz LeeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Haoxing LaiYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Hung Wei NgYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Rachel Sj GohYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Bryan ChongYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Mark D MuthiahYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Chin Meng KhooYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Jiong-Wei WangYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Gary TseDepartment of Cardiology, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China.
Poay Huan LohYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Anurag MehtaDivision of Cardiology, Department of Internal Medicine, VCU Health Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Adrian BrownUCL Centre for Obesity Research, University College London, London, Greater London, United Kingdom.
Georgios K DimitriadisDepartment of Endocrinology ASO/EASO COM, King's College Hospital NHS Foundation Trust, London, United Kingdom.
Mark Y ChanYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Nicholas W S ChewDepartment of Cardiology, National University Heart Centre, National University Health System, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There is emerging evidence that malnutrition is associated with poor prognosis among patients with acute coronary syndrome (ACS). Objectives: This study seeks to elucidate the prognostic impact of malnutrition in patients with ACS and provide a quantitative review of most commonly used nutritional assessment tools. Methods: Medline and Embase were searched for studies reporting outcomes in patients with malnutrition and ACS. Nutritional screening tools of interest included the Prognostic Nutrition Index, Geriatric Nutritional Risk Index, and Controlling Nutritional Status. A comparative meta-analysis was used to estimate the risk of all-cause mortality and cardiovascular events based on the presence of malnutrition and stratified according to ACS type, ACS intervention, ethnicity, and income. Results: Thirty studies comprising 37,303 patients with ACS were included, of whom 33.5% had malnutrition. In the population with malnutrition, the pooled mortality rate was 20.59% (95% CI: 14.95%-27.67%). Malnutrition was significantly associated with all-cause mortality risk after adjusting for confounders including age and left ventricular ejection fraction (adjusted HR: 2.66, 95% CI: 1.78-3.96, Conclusions: Malnutrition was significantly associated with all-cause mortality risk following ACS, regardless of ACS type, ethnicity, and income status, underscoring the importance of screening and interventional strategies for patients with malnutrition.

Indexed as

acute coronary syndromecoronary artery diseasemalnutritionnutritional assessment toolsprognosissystematic review and meta-analysis

Identifiers

PMID38938362
PMCPMC11198676

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.