ReviewJournal of applied toxicology : JAT2025
Impact of oxidative stress induced by heavy metals on ovarian function.
Review in Journal of applied toxicology : JAT, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessment of ovarian dysfunction induced by environmental toxins: a systematic review.Frontiers in public health · 2025Pooled it
- The Effects of Microplastics and Trace Elements on Ovarian Function and Pathology: A Literature Review.International journal of molecular sciences · 2026Review
- Seasonal and spatial assessment of aquatic pollution in the Mediterranean crab Callinectes sapidus.Scientific reports · 2026Article
- Role of NOX4 and GSH in Cadmium-Induced Renal Redox Homeostatic Dysregulation of Rats and APO Intervention Effect Study.Biological trace element research · 2026Article
- Serum trace and heavy metal exposure and IVF/ICSI outcomes: modifying effects of maternal diet in a prospective cohort.Reproductive biology and endocrinology : RB&E · 2026Article
- Nano-formulated curcumin restores hypothalamic-pituitary-ovarian axis disturbance in cadmium-induced female reproductive toxicity.Open veterinary journal · 2026Article
- Relationship between different modes of death and premature ovarian insufficiency: a literature review.Apoptosis : an international journal on programmed cell death · 2026Review
- Oxidative Stress andInternational journal of molecular sciences · 2026Review
- The Impact of Oxidative Stress Imbalance on Ovarian Function and Its Mechanisms.International journal of general medicine · 2026Review
- Evaluation of the protective effects of green tea for ischemia-reperfusion injury in rat ovary tissue: an experimental study.Acta cirurgica brasileira · 2026Article
- Chronic heavy metal exposure in Yunnan Province disrupts intestinal defenses and increases susceptibility to pathogens: an integrative review.Frontiers in public health · 2026Review
- Investigating the Impact of Bismuth Oxide Nanoparticles on Dazl Gene Expression and Spermatogenesis Indices in Male Mice.Biological trace element research · 2025Article
- Environmental heavy metal exposure and altering anti-Mullerian hormone levels in women.BMC women's health · 2025Article
- New Approaches and Strategies for the Repurposing of Iron Chelating/Antioxidant Drugs for Diseases of Free Radical Pathology in Medicine.Antioxidants (Basel, Switzerland) · 2025Review
- Protective Effects of Gallic Acid Against Lead Acetate- Induced Toxicity in Mice Ovary: Focus on Apoptosis, Inflammation, and Folliculogenesis.Food science & nutrition · 2025Article
- Unveiling the nexus between environmental exposures and testicular damages: revelations from autophagy and oxidative stress imbalance.Cell death discovery · 2025Review
- The Importance of Mitochondrial Processes in the Maturation and Acquisition of Competences of Oocytes and Embryo Culture.International journal of molecular sciences · 2025Review
- Impact of oxidative stress induced by heavy metals on ovarian function.Journal of applied toxicology : JAT · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
As a crucial organ of the female reproductive system, the ovary has both reproductive and endocrine functions. Oxidative stress refers to an increase in intracellular reactive oxygen species (ROS), which play a role in the normal physiological activity of the ovary. However, excessive ROS can cause damage to the ovary. With the advancement of human industrial activities, heavy metal pollution has become increasingly severe. Heavy metals cause oxidative stress through both direct and indirect mechanisms, leading to changes in signal transduction pathways that damage the ovaries. This review aims to outline the adverse effects of oxidative stress on the ovaries triggered by heavy metals such as copper, arsenic, cadmium, mercury, and lead. The detrimental effects of heavy metals on ovaries include follicular atresia and decreased estrogen production in experimental animals, and they also cause premature ovarian insufficiency in women. Additionally, this review discusses the role of antioxidants, provides some treatment methods, summarizes the limitations of current research, and offers perspectives for future research directions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.