Evidence map›Paper›PMID 38937838›Full record

ArticleCell & bioscience2024

Generation and transcriptomic characterization of MIR137 knockout miniature pig model for neurodevelopmental disorders.

Shengyun Xu, Jiaoxiang Wang, Kexin Mao, Deling Jiao, Zhu Li, Heng Zhao, Yifei Sun, Jin Feng, Yuanhao Lai, Ruiqi Peng and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shengyun Xu *Institute of Biomedical Research, Yunnan University, Kunming, 650500, China.
Jiaoxiang Wang *Key Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Yunnan Agricultural University, Kunming, 650201, China.
Kexin Mao *Institute of Biomedical Research, Yunnan University, Kunming, 650500, China.
Deling Jiao *Key Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Yunnan Agricultural University, Kunming, 650201, China.
Zhu LiInstitute of Biomedical Research, Yunnan University, Kunming, 650500, China.
Heng ZhaoKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Yunnan Agricultural University, Kunming, 650201, China.
Yifei SunInstitute of Biomedical Research, Yunnan University, Kunming, 650500, China.
Jin FengInstitute of Biomedical Research, Yunnan University, Kunming, 650500, China.
Yuanhao LaiInstitute of Biomedical Research, Yunnan University, Kunming, 650500, China.
Ruiqi PengInstitute of Biomedical Research, Yunnan University, Kunming, 650500, China.
Yu FuInstitute of Biomedical Research, Yunnan University, Kunming, 650500, China.
Ruoyi GanInstitute of Biomedical Research, Yunnan University, Kunming, 650500, China.
Shuhan ChenKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Yunnan Agricultural University, Kunming, 650201, China.
Hong-Ye ZhaoKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Yunnan Agricultural University, Kunming, 650201, China. hyzhao2000@126.com.
Hong-Jiang WeiKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Yunnan Agricultural University, Kunming, 650201, China. hongjiangwei@126.com.
Ying ChengInstitute of Biomedical Research, Yunnan University, Kunming, 650500, China. ycheng@ynu.edu.cn.ORCID http://orcid.org/0000-0002-4233-5330

Funding

Key Technologies Research and Development Program 2020YFA0509000Major Science and Technology Projects in Yunnan Province 202102AA100054National Natural Science Foundation of China 82071540
6 · The paper itself

Abstract

backgroundNeurodevelopmental disorders (NDD), such as autism spectrum disorders (ASD) and intellectual disorders (ID), are highly debilitating childhood psychiatric conditions. Genetic factors are recognized as playing a major role in NDD, with a multitude of genes and genomic regions implicated. While the functional validation of NDD-associated genes has predominantly been carried out using mouse models, the significant differences in brain structure and gene function between mice and humans have limited the effectiveness of mouse models in exploring the underlying mechanisms of NDD. Therefore, it is important to establish alternative animal models that are more evolutionarily aligned with humans.

resultsIn this study, we employed CRISPR/Cas9 and somatic cell nuclear transplantation technologies to successfully generate a knockout miniature pig model of the MIR137 gene, which encodes the neuropsychiatric disorder-associated microRNA miR-137. The homozygous knockout of MIR137 (MIR137

conclusionsOur study highlights the impact of miR-137 loss on critical genes involved in neurodevelopment and related disorders in MIR137

Indexed as

Animal modelAutism spectrum disordersIntellectual disordersmiR-137Neurodevelopmental disorderPig

Identifiers

PMID38937838
PMCPMC11212353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.