Evidence map›Paper›PMID 38937824›Full record

ArticleTrials2024

Virtual reality cue-exposure therapy in reducing cocaine craving: the Promoting Innovative COgnitive behavioral therapy for Cocaine use disorder (PICOC) study protocol for a randomized controlled trial.

T Lehoux, Antonio Capobianco, Jérôme Lacoste, Sloane Rollier, Yann Mopsus, Manuela Melgire, Flavien Lecuyer, Miguel Gervilla, Luisa Weiner

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05833529 (Virtual Reality Cue Exposure Therapy for Cocaine Craving), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05833529 naunknown statusnot on this map

Virtual Reality Cue Exposure Therapy for Cocaine Craving: an Innovative Cognitive and Behavioral Psychotherapy for Cocaine Use Disorder (Psychothérapie Innovante COmportementale et Cognitive Pour le Trouble d'Usage de Cocaïne; PICOC)

TypeinterventionalSponsorThomas LehouxRan2023 to 2025Enrolled54ConditionsCocaine Use DisorderArmsVirtual Reality Cue Exposure (VRCE) Therapy for Cocaine Craving - 2 weeks, Memory Focused Cognitive Therapy (MFCT) - 1 week, Pictures-based Cue Exposure (PCE) Therapy for Cocaine Craving - 3 weeks
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

T LehouxLaboratoire de Psychologie Des Cognitions, University of Strasbourg, 4 Rue Blaise Pascal, 67081, Strasbourg, France. thomas.lehoux@hotmail.fr.ORCID http://orcid.org/0000-0003-2637-5735
Antonio CapobiancoLaboratoire ICube - Equipe IGG, University of Strasbourg, 300 Boulevard Sébastien Brant, 67412, Illkirch, France.
Jérôme LacosteService d'Addictologie, University Hospital of Martinique - Hôpital Pierre Zobda-Quitman (CHU de Martinique), CS 90632 - 97261, Fort-de-France Martinique, France.
Sloane RollierResearch Methodological Support (USMR), Délégation à La Recherche Clinique et à L'Innovation, University Hospital of Martinique - Hôpital Pierre Zobda-Quitman (CHU de Martinique), CS 90632 - 97261, Fort-de-France, Martinique, France.
Yann MopsusResearch Methodological Support (USMR), Délégation à La Recherche Clinique et à L'Innovation, University Hospital of Martinique - Hôpital Pierre Zobda-Quitman (CHU de Martinique), CS 90632 - 97261, Fort-de-France, Martinique, France.
Manuela MelgireDepartment of Addictology, CSAPA Saint-Esprit, Saint-Esprit Hospital (CH de Saint-Esprit), BP 176 Route du Petit-Bourg, 97270, Saint-Esprit, Martinique, France.
Flavien LecuyerLaboratoire ICube - Equipe IGG, University of Strasbourg, 300 Boulevard Sébastien Brant, 67412, Illkirch, France.
Miguel GervillaLaboratoire ICube - Equipe IGG, University of Strasbourg, 300 Boulevard Sébastien Brant, 67412, Illkirch, France.
Luisa WeinerLaboratoire de Psychologie Des Cognitions, University of Strasbourg, 4 Rue Blaise Pascal, 67081, Strasbourg, France.

Funding

Groupement Interrégional de Recherche Clinique et d'Innovation Sud-Ouest Outre-Mer Hospitalier APIDOM 2022Institut National Du Cancer SPAV1-22-023
6 · The paper itself

Abstract

backgroundCocaine craving is a central symptom of cocaine use disorders (CUD). Virtual reality cue-exposure therapy for craving (VRCET) allows more immersive, realistic, and controllable exposure than traditional non-VR cue-exposure therapy (CET), whose efficacy is limited in treating substance use disorders. The purpose of this study is to evaluate the efficacy and acceptability of VRCET, as a stand-alone and add-on intervention (i.e., combined with cognitive therapy), compared to a picture-based CET (PCET), in reducing self-reported cocaine craving in inpatients hospitalized for CUD.

methodsFifty-four inpatients hospitalized for CUD will be randomized in one of two intensive 3-week treatment arms: 10 meetings/2-week treatment of VRCET plus 5 meetings/1-week treatment of memory-focused cognitive therapy (MFCT; experimental arm), or 15 meetings/3-week treatment of PCET (active control arm). The Craving Experience Questionnaire (CEQ - F & S) will be used to assess the primary outcome, i.e., the post-treatment decrease of self-reported cocaine craving frequency (within the past 2 weeks) and intensity scores (in VR exposure to cocaine cues). Secondary endpoints include urinary, physiological, and self-reported cocaine use-related measures. Assessments are scheduled at pretreatment, after 2 weeks of treatment (i.e., VRCET vs. PCET), post-treatment (3 weeks, i.e., VRCET + MFCT vs. PCET), and at 1-month follow-up. Acceptability will be evaluated via (i) the Spatial Presence for Immersive Environments - Cybersickness along VRCET and (ii) the Client Satisfaction Questionnaires after 2 weeks of treatment and post-treatment. DISCUSSION: This study will be the first to evaluate the acceptability and efficacy of VRCET for CUD, as a psychotherapeutic add-on, to reduce both cocaine craving frequency and intensity. Additionally, this study will provide evidence about the specific interest of VRCET, compared to a non-VR-based CET, as a cue reactivity and exposure paradigm for treating substance use disorders.

trial registrationNCT05833529 [clinicaltrials.gov]. Prospectively registered on April 17, 2023.

Indexed as

Cocaine-Related DisordersCognitive Behavioral TherapyCravingCuesVirtual Reality Exposure TherapyAdultFemaleHumansMaleRandomized Controlled Trials as TopicTime FactorsTreatment OutcomeCocaine cravingCocaine use disorderCognitive behavioral therapyCue-exposure therapy (CET)Memory-focused cognitive therapy (MFCT)Virtual reality cue-exposure therapy (VRCET)

Identifiers

PMID38937824
PMCPMC11212420

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.