Evidence map›Paper›PMID 38937762›Full record

ArticleNutrition & metabolism2024

Cumulative exposure to AHA Life's Essential 8 is associated with nonalcoholic fatty liver disease: a large cohort study.

Wang Yaqin, Deng Shuwen, Yuan Ting, Zhu Xiaoling, Deng Yuling, Liu Lei, Wang Changfa

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Article in Nutrition & metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wang YaqinHealth Management Center, The Third Xiangya Hospital, Central South University, Yuelu District, No.138 Tongzipo Road, Changsha, 410013, Hunan, China.
Deng ShuwenHealth Management Center, The Third Xiangya Hospital, Central South University, Yuelu District, No.138 Tongzipo Road, Changsha, 410013, Hunan, China.
Yuan TingHealth Management Center, The Third Xiangya Hospital, Central South University, Yuelu District, No.138 Tongzipo Road, Changsha, 410013, Hunan, China.
Zhu XiaolingHealth Management Center, The Third Xiangya Hospital, Central South University, Yuelu District, No.138 Tongzipo Road, Changsha, 410013, Hunan, China.
Deng YulingHealth Management Center, The Third Xiangya Hospital, Central South University, Yuelu District, No.138 Tongzipo Road, Changsha, 410013, Hunan, China.
Liu Lei *Health Management Center, The Third Xiangya Hospital, Central South University, Yuelu District, No.138 Tongzipo Road, Changsha, 410013, Hunan, China. liulei19890403@163.com.ORCID http://orcid.org/0000-0002-3448-4264
Wang Changfa *General Surgery Department, The Third Xiangya Hospital, Central South University, Yuelu District, No.138 Tongzipo Road, Changsha, 410013, Hunan, China. wongdove@163.com.

Funding

Changsha Natural Science Foundation kq2208351Health Research Project of Hunan Provincial Health Commission W20243214Natural Science Foundation of Hunan Province 2024JJ5543 and 2024JJ5521
6 · The paper itself

Abstract

BACKGROUND AND

aimWe aimed to explore the associations of baseline and cumulative cardiovascular health with nonalcoholic fatty liver disease (NAFLD) development and regression using the new Life's Essential 8 score.

methodsFrom a health screening database, participants who underwent at least 4 health examinations between 2012 and 2022 were recruited and categorized into two cohorts: (a) the NAFLD development cohort with no history of NAFLD prior to Exam 4 and (b) the NAFLD regression cohort with diagnosed NAFLD prior to Exam 4. The LE8 score was calculated from each component. The outcomes were defined as newly incident NAFLD or regression of existing NAFLD from Exam 4 to the end of follow-up.

resultsIn the NAFLD development cohort, of 21,844 participants, 3,510 experienced incident NAFLD over a median follow-up of 2.3 years. Compared with the lowest quartile of cumulative LE8, individuals in the highest quartile conferred statistically significant 76% lower odds (hazard ratio [HR] 0.24, 95% confidence interval [CI], 0.21-0.28) of NAFLD incidence, and corresponding values for baseline LE8 were 42% (HR 0.58, 95% CI 0.53-0.65). In the NAFLD regression cohort, of 6,566 participants, 469 experienced NAFLD regression over a median follow-up of 2.4 years. Subjects with the highest quartile of cumulative LE8 had 2.03-fold (95% CI, 1.51-2.74) higher odds of NAFLD regression, and corresponding values for baseline LE8 were 1.61-fold (95% CI, 1.24-2.10).

conclusionCumulative ideal cardiovascular health exposure is associated with reduced NAFLD development and increased NAFLD regression. Improving and preserving health behaviors and factors should be emphasized as an important part of NAFLD prevention and intervention strategies.

Indexed as

AHA Life's essential 8CohortDevelopmentNonalcoholic Fatty Liver DiseaseRegression

Identifiers

PMID38937762
PMCPMC11212352

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