Evidence map›Paper›PMID 38937637›Full record

ArticleNature plants2024

Coexpression enhances cross-species integration of single-cell RNA sequencing across diverse plant species.

Michael John Passalacqua, Jesse Gillis

Abstract read
In one paragraph

Article in Nature plants, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Michael John PassalacquaGenomics Department, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. passala@cshl.edu.ORCID 0000-0002-6344-1175
Jesse GillisGenomics Department, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. jesse.gillis@utoronto.ca.ORCID 0000-0002-0936-9774

Funding

Revealing the transcriptomic basis of neuronal identity through functional meta-analysisR01MH113005 · NIMH · COLD SPRING HARBOR LABORATORY · PI GILLIS, JESSE · 2017 to 2021
$2.4M
NIMH NIH HHS R01 MH113005NSF | BIO | Division of Integrative Organismal Systems (IOS) NSF IOS-1934388U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) NIH R01 MH113005
6 · The paper itself

Abstract

Single-cell RNA sequencing is increasingly used to investigate cross-species differences driven by gene expression and cell-type composition in plants. However, the frequent expansion of plant gene families due to whole-genome duplications makes identification of one-to-one orthologues difficult, complicating integration. Here we demonstrate that coexpression can be used to trim many-to-many orthology families down to identify one-to-one gene pairs with proxy expression profiles, improving the performance of traditional integration methods and reducing barriers to integration across a diverse array of plant species.

Indexed as

Sequence Analysis, RNASingle-Cell AnalysisGene Expression Regulation, PlantPlantsRNA, PlantSpecies SpecificityRNA, Plant

Identifiers

PMID38937637
PMCPMC11266096

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.