Evidence map›Paper›PMID 38937580›Full record

ArticleNpj mental health research2024

Trajectories of improvement with repetitive transcranial magnetic stimulation for treatment-resistant major depression in the BRIGhTMIND trial.

P M Briley, L Webster, S Lankappa, S Pszczolkowski, R H McAllister-Williams, P F Liddle, D P Auer, R Morriss

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Npj mental health research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

P M BrileyMental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK. paul.briley@nottingham.ac.uk.
L WebsterNottingham National Institute for Health and Care Research (NIHR) Biomedical Research Centre, Nottingham, UK.
S LankappaNottinghamshire Healthcare NHS Foundation Trust, Nottingham, UK.
S PszczolkowskiMental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK.
R H McAllister-WilliamsTranslational and Clinical Research Institute and Northern Centre for Mood Disorders, Newcastle University, Newcastle upon Tyne, UK.
P F LiddleMental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK.
D P AuerMental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK.
R MorrissMental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK.

Funding

Efficacy and Mechanism Evaluation Programme 16/44/02
6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is an established non-invasive brain stimulation treatment for major depressive disorder, but there is marked inter-individual variability in response. Using latent class growth analysis with session-by-session patient global impression ratings from the recently completed BRIGhTMIND trial, we identified five distinct classes of improvement trajectory during a 20-session treatment course. This included a substantial class of patients noticing delayed onset of improvement. Contrary to prior expectations, members of a class characterised by early and continued improvement showed greatest inter-session variability in stimulated location. By relating target locations and inter-session variability to a well-studied atlas, we estimated an average of 3.0 brain networks were stimulated across the treatment course in this group, compared to 1.1 in a group that reported symptom worsening (p < 0.001, d = 0.893). If confirmed, this would suggest that deliberate targeting of multiple brain networks could be beneficial to rTMS outcomes.

Identifiers

PMID38937580
PMCPMC11211415

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.