Evidence map›Paper›PMID 38937567›Full record

ArticleScientific reports2024

Detection of early-stage NASH using non-invasive hyperpolarized

Cornelius von Morze, Tyler Blazey, Ashley Shaw, William M Spees, Kooresh I Shoghi, Michael A Ohliger

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Complementary hyperpolarizedNpj imaging · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cornelius von MorzeMallinckrodt Institute of Radiology, Washington University, 4525 Scott Ave Rm 2303, St. Louis, MO, 63110, USA. cornelius@wustl.edu.
Tyler BlazeyMallinckrodt Institute of Radiology, Washington University, 4525 Scott Ave Rm 2303, St. Louis, MO, 63110, USA.
Ashley ShawMallinckrodt Institute of Radiology, Washington University, 4525 Scott Ave Rm 2303, St. Louis, MO, 63110, USA.
William M SpeesMallinckrodt Institute of Radiology, Washington University, 4525 Scott Ave Rm 2303, St. Louis, MO, 63110, USA.
Kooresh I ShoghiMallinckrodt Institute of Radiology, Washington University, 4525 Scott Ave Rm 2303, St. Louis, MO, 63110, USA.
Michael A OhligerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Novel hyperpolarized 13C molecular imaging techniques for differentiating NAFLD and NASHR01DK115987 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OHLIGER, MICHAEL, VON MORZE, CORNELIUS · 2018 to 2022
$2.1M
PURCHASE OF A GE SPINLAB HYPERPOLARIZATION UNIT FOR PRECLINICAL IMAGINGS10OD023580 · OD · WASHINGTON UNIVERSITY · PI ACKERMAN, JOSEPH J. H. · 2017 to 2017
$1.9M
NCI NIH HHS P30 CA091842NIBIB NIH HHS P41 EB013598NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK115987NIH HHS R01DK115987NIH HHS S10 OD023580NIH HHS S10OD023580
6 · The paper itself

Abstract

Non-alcoholic steatohepatitis (NASH) is characterized from its early stages by a profound remodeling of the liver microenvironment, encompassing changes in the composition and activities of multiple cell types and associated gene expression patterns. Hyperpolarized (HP)

Indexed as

Carbon IsotopesDiagnostic ImagingNon-alcoholic Fatty Liver DiseaseAnimalsCarbon-13 Magnetic Resonance SpectroscopyCholineCytoplasmDietGene Expression RegulationLiverMaleMethionineRats, Sprague-DawleyTranscriptomeCarbon-13Carbon IsotopesCholineMethionine

Identifiers

PMID38937567
PMCPMC11211431

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.