Evidence map›Paper›PMID 38937505›Full record

ArticleScientific reports2024

First in vitro cell co-culture experiments using laser-induced high-energy electron FLASH irradiation for the development of anti-cancer therapeutic strategies.

Stefana Orobeti, Livia Elena Sima, Ioana Porosnicu, Constantin Diplasu, Georgiana Giubega, Gabriel Cojocaru, Razvan Ungureanu, Cosmin Dobrea, Mihai Serbanescu, Alexandru Mihalcea and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Stefana Orobeti *National Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Livia Elena Sima *Department of Molecular Cell Biology, Institute of Biochemistry of the Romanian Academy, 296 Splaiul Independentei, 060031, Bucharest, Romania.
Ioana PorosnicuNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Constantin DiplasuNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Georgiana GiubegaNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Gabriel CojocaruNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Razvan UngureanuNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Cosmin DobreaNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Mihai SerbanescuNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Alexandru MihalceaNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Elena StancuNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Cristina Elena StaicuNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Florin JipaNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Alexandra BranNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Emanuel AxenteNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Simion SandelNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Marian ZamfirescuNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Ion TiseanuNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania.
Felix SimaNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, RO-077125, Magurele, Romania. felix.sima@inflpr.ro.

Funding

IFA (Institute of Atomic Physics) ELI-RO_2020_11 Project, No. 01/2020Laserlab-Europe Grant No. 871124Romanian Academy No. 1/2023Romanian Ministry of Education and Research LAPLAS VII No. 30N/2023UEFISCDI PCE No. 8/2021
6 · The paper itself

Abstract

Radiation delivery at ultrahigh dose rates (UHDRs) has potential for use as a new anticancer therapeutic strategy. The FLASH effect induced by UHDR irradiation has been shown to maintain antitumour efficacy with a reduction in normal tissue toxicity; however, the FLASH effect has been difficult to demonstrate in vitro. The objective to demonstrate the FLASH effect in vitro is challenging, aiming to reveal a differential response between cancer and normal cells to further identify cell molecular mechanisms. New high-intensity petawatt laser-driven accelerators can deliver very high-energy electrons (VHEEs) at dose rates as high as 10

Indexed as

Coculture TechniquesElectronsLasersCell Line, TumorDNA Breaks, Double-StrandedDNA DamageHumansMelanocytesMelanoma

Identifiers

PMID38937505
PMCPMC11211417

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.