ArticleNature communications2024
Superporous sponge prepared by secondary network compaction with enhanced permeability and mechanical properties for non-compressible hemostasis in pigs.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Fetal Bovine Hide Collagen-Chitosan Composite Sponges: Preparation, Physicochemical Profiling, and Cutaneous Wound Healing Efficacy.Polymers · 2026Article
- Unveiling Photo-Thermal-Electrical Performance in Robust, Self-Healing, and Anti-Freezing Cellulose-MXene Eutectogels for Advanced Hemostasis.Nano-micro letters · 2026Article
- Natural Polymer-Based Hemostatic Hydrogels with Advanced Material and Structural Designs for Functional Applications.Pharmaceutics · 2026Review
- Ultra-fast self-gelling self-expanding self-propelling high-adhesion procoagulant hemostatic powder for non-compressible hemorrhage hemostasis in pigs.Nature communications · 2026Article
- Chitosan-Based Wound Dressings: Property Modulation, Fabrication Strategies, and Emerging Applications in Tissue Regeneration.International journal of nanomedicine · 2026Review
- AlN-based aerogel thermo-cooler enabled by enhanced phonon conduction and unconstrained liquid capillarity.Nature communications · 2025Article
- Mechanoadaptive polysaccharide conjugates architect pro-healing microenvironments via dynamic stress redistribution in skin defects.Science advances · 2025Article
- All-in-one extracellular matrix-based powders with instant self-assembly and multiple bioactivities integrate hemostasis and in-situ tissue functional repair.Bioactive materials · 2025Article
- A self-adhesive hierarchical nanofiber patch for dynamic and multistage management of full-thickness cutaneous wounds.Journal of nanobiotechnology · 2025Article
- Bicomponent nano- and microfiber aerogels for effective management of junctional hemorrhage.Nature communications · 2025Article
- Water absorption dynamics in medical foam: empirical validation of the Lucas-Washburn model.The European physical journal. E, Soft matter · 2025Article
- Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions.Bioactive materials · 2025Review
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developing superporous hemostatic sponges with simultaneously enhanced permeability and mechanical properties remains challenging but highly desirable to achieve rapid hemostasis for non-compressible hemorrhage. Typical approaches to improve the permeability of hemostatic sponges by increasing porosity sacrifice mechanical properties and yield limited pore interconnectivity, thereby undermining the hemostatic efficacy and subsequent tissue regeneration. Herein, we propose a temperature-assisted secondary network compaction strategy following the phase separation-induced primary compaction to fabricate the superporous chitosan sponge with highly-interconnected porous structure, enhanced blood absorption rate and capacity, and fatigue resistance. The superporous chitosan sponge exhibits rapid shape recovery after absorbing blood and maintains sufficient pressure on wounds to build a robust physical barrier to greatly improve hemostatic efficiency. Furthermore, the superporous chitosan sponge outperforms commercial gauze, gelatin sponges, and chitosan powder by enhancing hemostatic efficiency, cell infiltration, vascular regeneration, and in-situ tissue regeneration in non-compressible organ injury models, respectively. We believe the proposed secondary network compaction strategy provides a simple yet effective method to fabricate superporous hemostatic sponges for diverse clinical applications.
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