Evidence map›Paper›PMID 38937448›Full record

ArticleNature communications2024

Distributable, metabolic PET reporting of tuberculosis.

R M Naseer Khan, Yong-Mo Ahn, Gwendolyn A Marriner, Laura E Via, Francois D'Hooge, Seung Seo Lee, Nan Yang, Falguni Basuli, Alexander G White, Jaime A Tomko and 20 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Discovery of a Thermostable Nigerose Phosphorylase for the Efficient Chemoenzymatic Radiosynthesis of aJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  4. The role of medical imaging in translational research into early pulmonary tuberculosis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
    Review
  5. Article
  6. Cassette-Based Automated Production of 2-Deoxy-2-[Molecules (Basel, Switzerland) · 2026
    Article
  7. Article
  8. Review
  9. Tre-DST: A Drug Susceptibility Test forACS infectious diseases · 2026
    Article
  10. Article
  11. Article
  12. Comparative Study of [Molecular imaging and biology · 2025
    Article
  13. Review
  14. Article
  15. Review
  16. European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors.

R M Naseer Khan *Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, UK.ORCID 0000-0001-6875-1669
Yong-Mo Ahn *Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Gwendolyn A Marriner *Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Laura E Via *Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0001-6074-9521
Francois D'HoogeDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, UK.
Seung Seo LeeDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, UK.ORCID 0000-0002-8598-3303
Nan YangDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, UK.
Falguni BasuliChemistry and Synthesis Center, NHLBI, NIH, Bethesda, MD, USA.
Alexander G WhiteDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, USA.
Jaime A TomkoDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, USA.
L James FryeDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, USA.
Charles A ScangaDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, USA.ORCID 0000-0003-3654-5603
Danielle M WeinerTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Michelle L SutphenTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Daniel M SchimelTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Emmanuel DayaoTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Michaela K PiazzaTuberculosis Imaging Program, DIR, NIAID, NIH, Bethesda, MD, USA.
Felipe GomezTuberculosis Imaging Program, DIR, NIAID, NIH, Bethesda, MD, USA.
William DieckmannPositron Emission Tomography Department, Clinical Center, NIH, Bethesda, MD, USA.
Peter HerscovitchPositron Emission Tomography Department, Clinical Center, NIH, Bethesda, MD, USA.
N Scott MasonDepartment of Radiology, University of Pittsburgh, Pittsburgh, USA.
Rolf SwensonChemistry and Synthesis Center, NHLBI, NIH, Bethesda, MD, USA.
Dale O KiesewetterMolecular Tracer and Imaging Core Facility, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD, USA.
Keriann M BackusDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, UK.
Yiqun GengDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, UK.ORCID 0009-0001-5953-2912
Ritu RajDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, UK.
Daniel C AnthonyDepartment of Pharmacology, University of Oxford, Oxford, UK.ORCID 0000-0003-1380-6655
JoAnne L FlynnDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, USA.ORCID 0000-0001-7874-8981
Clifton E BarryTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA. CBARRY@niaid.nih.gov.ORCID 0000-0002-2927-270X
Benjamin G DavisDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, UK. Ben.Davis@rfi.ac.uk.ORCID 0000-0002-5056-407X

Funding

Tuberculosis Imaging ProgramZICAI001239 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2018 to 2025
$22.7M
Imaging Probe Development CenterZICHL005090 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SWENSON, ROLF · 2011 to 2025
$22.2M
Experimental Animal Models of TB: Chemotherapeutics and ImagingZIAAI000734 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARRY, CLIFTON · 2009 to 2025
$19.6M
CAP: Development of a Tuberculosis-Specific PET Imaging AgentZIAAI001164 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARRY, CLIFTON · 2012 to 2017
$1.3M
Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) OPP1034408Intramural NIH HHS ZIA AI001164RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/R511742/1RCUK | Engineering and Physical Sciences Research Council (EPSRC) V011359/1
6 · The paper itself

Abstract

Tuberculosis remains a large global disease burden for which treatment regimens are protracted and monitoring of disease activity difficult. Existing detection methods rely almost exclusively on bacterial culture from sputum which limits sampling to organisms on the pulmonary surface. Advances in monitoring tuberculous lesions have utilized the common glucoside [

Indexed as

Mycobacterium tuberculosisPositron-Emission TomographyTrehaloseTuberculosisAnimalsDisease Models, AnimalFemaleFluorine RadioisotopesFluorodeoxyglucose F18HumansMiceRadiopharmaceuticalsFluorine-18Fluorine RadioisotopesFluorodeoxyglucose F18RadiopharmaceuticalsTrehalose

Identifiers

PMID38937448
PMCPMC11211441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.