Evidence map›Paper›PMID 38937427›Full record

ReviewPaediatric drugs2024

Commercial Versus Compounded Preparations in Pediatric Ophthalmology.

Annegret Dahlmann-Noor, Jill Bloom, Saw Keng Lee, Samiya Chowdhury, Kanwal Nischal, Dominique Bremond-Gignac

Abstract readReview
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In one paragraph

Review in Paediatric drugs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Annegret Dahlmann-NoorUniversity College London, Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK. Anngret.dahlmann@ucl.ac.uk.ORCID http://orcid.org/0000-0002-7402-4350
Jill BloomMoorfields Eye Hospital NHS Foundation Trust, 162 City Road, London, EC1V 2PD, UK.
Saw Keng LeeMoorfields Eye Hospital NHS Foundation Trust, 162 City Road, London, EC1V 2PD, UK.
Samiya ChowdhuryMoorfields Eye Hospital NHS Foundation Trust, 162 City Road, London, EC1V 2PD, UK.
Kanwal NischalThe Eye Centre, University of Pittsburgh Medical Centre Children's Hospital of Pittsburgh, 4401 Penn Ave, Pittsburgh, PA, 15224, USA.
Dominique Bremond-GignacOphthalmology Department, Necker-Enfants Malades University Hospital, AP-HP, Paris Cité University, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many conditions managed by pediatric ophthalmologists are rare diseases, and even if pharmacological treatments are available, these have often not been evaluated in children. Off-label prescribing is a common practice in pediatric ophthalmology. In addition, there is often no commercial case for the production of a medicine that may only be used for a small number of patients worldwide. Compounded preparations prepared locally are therefore still in frequent use, although it is known that production may not meet stringent quality assurance standards. For several indications, commercial preparations, evaluated in rigorous clinical trials with children, are now available. Myopia management is joining the list of these indications, with low-concentration atropine formulations derived from recent clinical trials in Australia, USA, and Europe now entering the market. This short article gives an overview of the background and recent developments of compounded and commercial preparations for use in pediatric ophthalmology.

Indexed as

Drug CompoundingOphthalmologyChildHumansOff-Label UseOphthalmic SolutionsPediatricsOphthalmic Solutions

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.