Evidence map›Paper›PMID 38937422›Full record

ArticleMolecular neurobiology2025

CDK5 Deficiency Does not Impair Neuronal Differentiation of Human Induced Pluripotent Stem Cells but Affects Neurite Outgrowth.

Sofía Mucci, Giulia Solange Clas, Camila Paola Allio, María Soledad Rodríguez-Varela, Luciana Isaja, Mariela Marazita, Gustavo Emilio Sevlever, María Elida Scassa, Leonardo Romorini

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sofía MucciLaboratorio de Investigación Aplicada a Neurociencias, Instituto de Neurociencias, Fundación Para La Lucha Contra Las Enfermedades Neurológicas de La Infancia (LIAN-INEU, Fleni-CONICET), B1625XAF, Belén de Escobar, Provincia de Buenos Aires, Argentina.
Giulia Solange ClasLaboratorio de Investigación Aplicada a Neurociencias, Instituto de Neurociencias, Fundación Para La Lucha Contra Las Enfermedades Neurológicas de La Infancia (LIAN-INEU, Fleni-CONICET), B1625XAF, Belén de Escobar, Provincia de Buenos Aires, Argentina.
Camila Paola AllioLaboratorio de Investigación Aplicada a Neurociencias, Instituto de Neurociencias, Fundación Para La Lucha Contra Las Enfermedades Neurológicas de La Infancia (LIAN-INEU, Fleni-CONICET), B1625XAF, Belén de Escobar, Provincia de Buenos Aires, Argentina.
María Soledad Rodríguez-VarelaLaboratorio de Investigación Aplicada a Neurociencias, Instituto de Neurociencias, Fundación Para La Lucha Contra Las Enfermedades Neurológicas de La Infancia (LIAN-INEU, Fleni-CONICET), B1625XAF, Belén de Escobar, Provincia de Buenos Aires, Argentina.
Luciana IsajaLaboratorio de Investigación Aplicada a Neurociencias, Instituto de Neurociencias, Fundación Para La Lucha Contra Las Enfermedades Neurológicas de La Infancia (LIAN-INEU, Fleni-CONICET), B1625XAF, Belén de Escobar, Provincia de Buenos Aires, Argentina.
Mariela MarazitaLaboratorio de Investigación Aplicada a Neurociencias, Instituto de Neurociencias, Fundación Para La Lucha Contra Las Enfermedades Neurológicas de La Infancia (LIAN-INEU, Fleni-CONICET), B1625XAF, Belén de Escobar, Provincia de Buenos Aires, Argentina.
Gustavo Emilio SevleverLaboratorio de Investigación Aplicada a Neurociencias, Instituto de Neurociencias, Fundación Para La Lucha Contra Las Enfermedades Neurológicas de La Infancia (LIAN-INEU, Fleni-CONICET), B1625XAF, Belén de Escobar, Provincia de Buenos Aires, Argentina.
María Elida ScassaLaboratorio de Investigación Aplicada a Neurociencias, Instituto de Neurociencias, Fundación Para La Lucha Contra Las Enfermedades Neurológicas de La Infancia (LIAN-INEU, Fleni-CONICET), B1625XAF, Belén de Escobar, Provincia de Buenos Aires, Argentina.
Leonardo RomoriniLaboratorio de Investigación Aplicada a Neurociencias, Instituto de Neurociencias, Fundación Para La Lucha Contra Las Enfermedades Neurológicas de La Infancia (LIAN-INEU, Fleni-CONICET), B1625XAF, Belén de Escobar, Provincia de Buenos Aires, Argentina. lromorini@fleni.org.ar.ORCID http://orcid.org/0000-0002-3972-0991

Funding

Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (ANPCyT) PICT-2016-2621
6 · The paper itself

Abstract

Cyclin-dependent kinase 5 (CDK5) is a protein kinase involved in neuronal homeostasis and development critical for neuronal survival. Besides, its deregulation is linked to neurodegenerative pathologies such as Alzheimer's and Parkinson's diseases. For that reason, we aimed to generate a deficient CDK5 genetic model in neurons derived from human-induced pluripotent stem cells (hiPSCs) using CRISPR/Cas9 technology. We obtained a heterozygous CDK5

Indexed as

Cell DifferentiationCyclin-Dependent Kinase 5Induced Pluripotent Stem CellsNeuronal OutgrowthCell ProliferationHumansNeural Stem CellsNeuritesNeurogenesisNeuronsCDK5 protein, humanCyclin-Dependent Kinase 5CDK5CRISPR/Cas9Human pluripotent stem cellsNeurons

Identifiers

PMID38937422

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.