Evidence map›Paper›PMID 38937374›Full record

ArticleWorld journal of microbiology & biotechnology2024

Transcriptomic and metabolomic analysis of prebiotics utilization by Bifidobacterium animalis.

Tong Liu, Huasong Bai, Songjun Wang, Wenhui Gong, Zhanzhong Wang

Abstract read
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In one paragraph

Article in World journal of microbiology & biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tong LiuNourse Science Centre for Pet Nutrition, Wuhu, 241200, China.
Huasong BaiNourse Science Centre for Pet Nutrition, Wuhu, 241200, China.
Songjun WangNourse Science Centre for Pet Nutrition, Wuhu, 241200, China.
Wenhui GongNourse Science Centre for Pet Nutrition, Wuhu, 241200, China.
Zhanzhong WangNourse Science Centre for Pet Nutrition, Wuhu, 241200, China. wzz7698@tju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, the utilization mechanism of oligosaccharides by Bifidobacterium was investigated through the transcriptome sequencing and non-targeted metabolomics technology of Bifidobacterium animalis cultured with fructo-oligosaccharides (FOS) and galacto-oligosaccharides (GOS). The results showed that FOS affected the synthesis of adenosine triphosphate binding transporters (ABC transporters) by increasing the expression levels of msmE, msmG, and gluA. Similarly, GOS improved aminoacyl-tRNA synthases by upregulating the expression of tRNA-Ala, tRNA-Pro, and tRNA-Met. Bifidobacterium animalis cultured with FOS and GOS produced different metabolites, such as histamine, tartaric acid, and norepinephrine, with the functions of inhibiting inflammation, alleviating depression and diseases related to brain and nervous system and maintaining body health. Furthermore, the transcriptome and metabolome analysis results revealed that FOS and GOS promoted the growth and metabolism of Bifidobacterium animalis by regulating the related pathways of carbohydrate, energy, and amino acid metabolism. Overall, the experimental results provided significant insights into the prebiotic effects of FOS and GOS.

Indexed as

Bifidobacterium animalisMetabolomicsOligosaccharidesPrebioticsTranscriptomeAmino AcidsATP-Binding Cassette TransportersBacterial ProteinsGene Expression ProfilingGene Expression Regulation, BacterialMetabolomeAmino AcidsATP-Binding Cassette TransportersBacterial ProteinsfructooligosaccharideOligosaccharidesPrebioticsBifidobacterium animalisFructo-oligosaccharidesGalacto-oligosaccharidesMetabolomicPrebiotic effectsTranscriptomic

Identifiers

PMID38937374

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.