Evidence map›Paper›PMID 38937308›Full record

ArticleInternational ophthalmology2024

Association of CUL4B with the pathogenesis of age-related cataract.

Cem Karaosmanoğlu, Saliha Handan Yıldız, Müberra Akdoğan, Müjgan Özdemir Erdoğan

Abstract read
PubMed Publisher
In one paragraph

Article in International ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cem KaraosmanoğluDepartment of Medical Genetics, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey. cemkaraosmanoglu@gmail.com.ORCID http://orcid.org/0000-0002-7503-4905
Saliha Handan YıldızDepartment of Medical Genetics, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.ORCID http://orcid.org/0000-0003-3727-3662
Müberra AkdoğanDepartment of Ophthalmology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.ORCID http://orcid.org/0000-0003-4846-312X
Müjgan Özdemir ErdoğanDepartment of Medical Genetics, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.ORCID http://orcid.org/0000-0002-3434-8545

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAge-related cataract (ARC) is the most common cause of visual impairment and blindness in older adults. However, the role of CUL4B in the ARC remains unclear. Therefore, we investigated CUL4B expression and its effects on apoptosis. MATERIALS AND

methodsCUL4B expression levels were detected by a quantitative real-time polymerase chain reaction from the anterior lens capsules of patients with ARC and HLE-B3 cells treated with different concentrations of H

resultsCUL4B expression was downregulated in the anterior lens capsules (P < 0.0001) and H

conclusionsCUL4B downregulation promotes the apoptosis of lens epithelial cells. Our study may help in understanding the role of CUL4B in ARC pathogenesis.

Indexed as

ApoptosisCataractCullin ProteinsAgedAgingBlotting, WesternFemaleGene Expression RegulationHumansIn Situ Nick-End LabelingLens Capsule, CrystallineMaleMiddle AgedReal-Time Polymerase Chain ReactionCUL4B protein, humanCullin ProteinsAge-related cataractApoptosisCullin-4BLens epithelial cellsPathogenesis

Identifiers

PMID38937308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.