ArticleCell and tissue research1985
Localization of serotonin in the hypothalamus and the mesencephalon of the guinea-pig. An immunohistochemical study using monoclonal antibodies.
Article in Cell and tissue research, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 20 citations in OpenAlex.
- Decreased serotonin transporter immunoreactivity in the human hypothalamic infundibular nucleus of overweight subjects.Frontiers in neuroscience · 2014Article
- The serotonin-immunoreactive system of the suprachiasmatic nucleus in the hibernating ground squirrel, Spermophilus richardsonii.Cell and tissue research · 1989Article
- Early ontogeny of serotonin-immunoreactivity in the sheep brain. An immunohistochemical study.Anatomy and embryology · 1988Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The distribution of serotonin in the hypothalamus and the mesencephalon of guinea-pigs pretreated with both pargyline and L-tryptophan was investigated immunohistochemically using monoclonal antibodies to 5-HT. 5-HT-positive fibers and varicosities appeared distributed throughout the hypothalamus. Some areas showed a greater density of immunoreactivity: the suprachiasmatic nucleus, the region of the supraoptic crest, the area of the medial forebrain bundle, the ventral part of the nucleus ventromedialis, the median eminence and the ventral part of the mammillary bodies. 5-HT nerve fibers were also scattered in the posterior lobe of the pituitary. An extensive supra-ependymal plexus of immunoreactive axons was observed in most ventricular regions. No 5-HT positive cell bodies were present in the hypothalamus of the guinea-pig under our experimental conditions, whereas an intense serotonin immunoreactivity was detected in perikarya of the brain stem. 5-HT cell bodies were found predominantly in the raphe region including the nucleus raphe dorsalis and raphe medianus, nucleus interpeduncularis, reticular formation and dorsal area of the medial lemniscus.
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