Evidence map›Paper›PMID 38937107›Full record

ArticleeNeuro2024

Sustained Inhibition of GABA-AT by OV329 Enhances Neuronal Inhibition and Prevents Development of Benzodiazepine Refractory Seizures.

Phillip L W Colmers, Muhammad Nauman Arshad, Jayanta Mukherjee, Shinghong Lin, Shu Fun Josephine Ng, Patrick Sarmiere, Paul A Davies, Stephen J Moss

Abstract read
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Efficacy of GABA aminotransferase inactivator OV329 in models of neuropathic and inflammatory pain without tolerance or addiction.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Phillip L W ColmersDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111.ORCID https://orcid.org/0000-0003-4826-0429
Muhammad Nauman ArshadDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111.ORCID https://orcid.org/0000-0002-2144-9718
Jayanta MukherjeeOvid Therapeutics, New York, New York 10001.
Shinghong LinOvid Therapeutics, New York, New York 10001.
Shu Fun Josephine NgDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111.ORCID https://orcid.org/0000-0003-4567-1409
Patrick SarmiereOvid Therapeutics, New York, New York 10001.
Paul A DaviesDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111.ORCID https://orcid.org/0000-0002-3973-3143
Stephen J MossDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111 stephen.moss@tufts.edu.

Funding

Studies on the structure of gamma-aminobutyric acid type A receptor subtypesR01MH118263 · NIMH · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2019 to 2023
$2.4M
Determining the effects of human KCC2 mutations on neuronal excitabilityR21NS111338 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW · 2019 to 2020
$454k
NIMH NIH HHS R01 MH118263NINDS NIH HHS R21 NS111338
6 · The paper itself

Abstract

γ-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the adult brain which mediates its rapid effects on neuronal excitability via ionotropic GABA

Indexed as

4-Aminobutyrate TransaminaseAnticonvulsantsBenzodiazepinesgamma-Aminobutyric AcidSeizuresAnimalsBrainDisease Models, AnimalElectroencephalographyFemaleMaleMiceMice, Inbred C57BLNeural InhibitionNeuronsStatus Epilepticus4-Aminobutyrate TransaminaseAnticonvulsantsBenzodiazepinesgamma-Aminobutyric AcidEEGGABAGABA-ATOV329seizuretonic inhibition

Identifiers

PMID38937107
PMCPMC11236575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.