Evidence map›Paper›PMID 38936657›Full record

ArticleNeuropharmacology2024

Negative allosteric modulation of CB

Vishakh Iyer, Shahin A Saberi, Romario Pacheco, Emily Fender Sizemore, Sarah Stockman, Abhijit Kulkarni, Lucas Cantwell, Ganesh A Thakur, Andrea G Hohmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. A Comprehensive 4-layeredCurrent pharmaceutical biotechnology · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Vishakh IyerProgram in Neuroscience, Indiana University, Bloomington, IN, USA; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Shahin A SaberiDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Romario PachecoDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Emily Fender SizemoreDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Sarah StockmanDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Abhijit KulkarniDepartment of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Lucas CantwellDepartment of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Ganesh A ThakurDepartment of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Andrea G HohmannProgram in Neuroscience, Indiana University, Bloomington, IN, USA; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA; Gill Center for Biomolecular Science, Indiana University, Bloomington, IN, USA. Electronic address: hohmanna@iu.edu.

Funding

Project 3 - In vivo pharmacology of cannabinoid receptor probesP01DA009158 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI Alexandros Makriyannis · 1994 to 2026
$26.0M
CB2 Cannabinoid Mechanisms for Suppressing Opioid Tolerance and DependenceR01DA047858 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI HOHMANN, ANDREA GRACE, MACKIE, KENNETH · 2019 to 2023
$2.6M
A Novel Pharmacotherapy for GlaucomaR01EY024717 · NEI · NORTHEASTERN UNIVERSITY · PI THAKUR, GANESH A · 2014 to 2018
$2.2M
Role of CB2 in Analgesic MechanismsR01DA041229 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI HOHMANN, ANDREA GRACE, MACKIE, KENNETH · 2016 to 2020
$1.8M
A Novel Mechanism for Decreasing Opioid RewardR21DA042584 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI HOHMANN, ANDREA GRACE, REBEC, GEORGE VINCENT · 2016 to 2017
$392k
Allosteric Modulators of CB1 Cannabinoid ReceptorR03DA027113 · NIDA · NORTHEASTERN UNIVERSITY · PI THAKUR, GANESH A · 2009 to 2010
$390k
NEI NIH HHS R01 EY024717NIDA NIH HHS P01 DA009158NIDA NIH HHS R01 DA041229NIDA NIH HHS R01 DA047858NIDA NIH HHS R03 DA027113NIDA NIH HHS R21 DA042584
6 · The paper itself

Abstract

The direct blockade of CB

Indexed as

Analgesics, OpioidDrug ToleranceMorphineRats, Sprague-DawleyReceptor, Cannabinoid, CB1Substance Withdrawal SyndromeAllosteric RegulationAnimalsMaleMiceMice, Inbred C57BLNociceptionProto-Oncogene Proteins c-fosRatsSignal TransductionAnalgesics, OpioidMorphineProto-Oncogene Proteins c-fosReceptor, Cannabinoid, CB1Allosteric modulatorCB(1)EndocannabinoidOpioidToleranceWithdrawal

Identifiers

PMID38936657
PMCPMC11261750

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.