Evidence map›Paper›PMID 38936656›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2024

Monitoring of Leishmania transmission in the postelimination phase: The potential of serological surveys.

Kristien Cloots, Om Prakash Singh, Abhishek Kumar Singh, Tulika Kumari Rai, Vishwa Deepak Tiwari, Aziza Neyaz, Sundaram Pandey, Vivek Kumar Scholar, Paritosh Malaviya, Epco Hasker and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kristien ClootsDepartment of Public Health, Institute of Tropical Medicine, Antwerp, Belgium. Electronic address: kcloots@itg.be.
Om Prakash SinghDepartment of Biochemistry, Institute of Sciences, Banaras Hindu University, Varanasi, India.
Abhishek Kumar SinghDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Tulika Kumari RaiDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Vishwa Deepak TiwariDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Aziza NeyazDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Sundaram PandeyDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Vivek Kumar ScholarDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Paritosh MalaviyaDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Epco HaskerDepartment of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.
Shyam SundarDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesMonitoring of Leishmania transmission is considered a strategic priority for sustaining elimination of visceral leishmaniasis as a public health problem in the Indian subcontinent. The objective of this study was to evaluate whether serological surveys can distinguish between communities with and without Leishmania transmission, and to assess which serological marker performs best.

methodsSeven villages were selected from Bihar and Uttar Pradesh state, India, and categorized as either currently endemic (CE), previously endemic (PE) or nonendemic (NE). Blood samples were analyzed with the rK39 RDT, direct agglutination test (DAT), and rK39 ELISA.

resultsContrary to the rK39 RDT and DAT, the rK39 ELISA showed a significant difference between all three categories of endemicity, with a seroprevalence of 5.21% in CE villages, 1.55% in PE villages, and 0.13% in NE villages. Even when only looking at the seroprevalence among children aged <10 years, the rK39 ELISA was still able to differentiate between villages with and without ongoing transmission.

conclusionOur findings suggest the rK39 ELISA to be the most promising marker for monitoring of Leishmania transmission. Further validation is required, and practical, context-adapted recommendations need to be formulated in order to guide policymakers toward meaningful and sustainable surveillance strategies in the post-elimination phase.

Indexed as

Antibodies, ProtozoanEnzyme-Linked Immunosorbent AssayLeishmaniasis, VisceralAdolescentAdultAgglutination TestsAntigens, ProtozoanChildChild, PreschoolFemaleHumansIndiaInfantMaleMiddle AgedSeroepidemiologic StudiesAntibodies, ProtozoanAntigens, ProtozoanIndiaMonitoring of infectionPost-elimination surveillanceSerosurveillanceVisceral leishmaniasis

Identifiers

PMID38936656
PMCPMC11442319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.