Evidence map›Paper›PMID 38936550›Full record

Observational studyThe Journal of nutrition2024

Age of Juice Introduction and Cardiometabolic Outcomes in Middle Childhood.

Priscilla K Clayton, Diane L Putnick, Ian R Trees, Sonia L Robinson, Thomas G O'Connor, Jordan N Tyris, Edwina H Yeung

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03106493 (Upstate New York Infant Development Screening Program), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03106493 completednot on this map

Upstate New York Infant Development Screening Program

TypeobservationalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran2008 to 2019Enrolled6,171ConditionsObesity, Blood Pressure, Motor Delay, Developmental DelayArmsNone (observational)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Priscilla K ClaytonEpidemiology Branch, Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Diane L PutnickEpidemiology Branch, Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States. Electronic address: putnickd@mail.nih.gov.
Ian R TreesEpidemiology Branch, Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States. Electronic address: ian.trees@nih.gov.
Sonia L RobinsonViolence Prevention Research Program, University of California at Davis, Sacramento, CA, United States; Department of Emergency Medicine, School of Medicine, UC Davis, Sacramento, CA, USA; California Firearm Violence Research Center, Sacramento, CA, USA. Electronic address: sonialr@umich.edu.
Thomas G O'ConnorDepartment of Psychiatry, Neuroscience, and Obstetrics and Gynecology, University of Rochester, Rochester, NY, United States. Electronic address: tom_oconnor@urmc.rochester.edu.
Jordan N TyrisDivision of Hospital Medicine, Children's National Hospital, Washington, DC, United States. Electronic address: jbarger@childrensnational.org.
Edwina H YeungEpidemiology Branch, Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States. Electronic address: edwina.yeung@nih.gov.

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Sally W Thurston · 1985 to 2026
$42.8M
Upstate KIDS Follow-Up StudyZIAHD008949 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YEUNG, EDWINA · 2015 to 2025
$4.8M
NIEHS NIH HHS P30 ES001247
6 · The paper itself

Abstract

backgroundThe American Academy of Pediatrics recommends juice introduction after 12 months of age. Juice consumption has been linked to childhood obesity and cardiometabolic risk.

objectivesTo examine the prospective relationship between the age of juice introduction and primary and secondary cardiometabolic outcomes in middle childhood.

methodsParents reported the age of juice introduction on Upstate KIDS questionnaires completed between 4 and 18 months. The quantity and type of juice introduced were not measured. Anthropometry, blood pressure (BP), and arterial stiffness by pulse wave velocity (PWV) were measured for 524 children (age, 8-10 y) at study visits (2017-2019). Age- and gender-adjusted z-scores were calculated using the Centers for Disease Control and Prevention reference for anthropometrics. Plasma lipids, hemoglobin A1c (HbA1c), and C-reactive protein (CRP) in a subset of children were also measured (n = 248). Associations between age at juice introduction (categorized as <6, 6 to <12, ≥12 months), and outcomes were estimated using mean differences and odds ratios, applying generalized estimating equations to account for correlations between twins.

resultsApproximately 18% of children were introduced to juice at <6 months, 52% between 6 and <12 months, and 30% ≥ 12 months of age. Children who were introduced to juice before 6 months had higher systolic BP (3.13 mmHg; 95% confidence interval [CI]: 0.52, 5.74), heart rate (4.46 bpm; 95% CI: 1.05, 7.87), and mean arterial pressure (2.08 mmHg; 95% CI: 0.15, 4.00) compared with those introduced ≥12 months after covariate adjustment including sociodemographic factors and maternal prepregnancy body mass index. No adjusted differences in anthropometry, lipids, HbA1c, and CRP levels were found.

conclusionsEarly juice introduction during infancy was associated with higher systolic BP, heart rate, and mean arterial pressure in middle childhood. This trial was registered at clinicaltrials.gov as NCT03106493 (https://clinicaltrials.gov/study/NCT03106493?term=upstate%20KIDS&rank=1).

Indexed as

Age FactorsCardiometabolic Risk FactorsFruit and Vegetable JuicesBlood PressureCardiovascular DiseasesChildC-Reactive ProteinFemaleHumansInfantMalePediatric ObesityProspective StudiesPulse Wave AnalysisC-Reactive Proteincardiometabolic outcomeschildhoodearly infant feeding practicesjuicepediatric nutrition

Identifiers

PMID38936550
PMCPMC11375467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.