Evidence map›Paper›PMID 38936497›Full record

ArticleEnvironmental research2024

Exposure to per- and polyfluoroalkyl substances and alterations in plasma microRNA profiles in children.

Yijie Li, Brittney O Baumert, Nikos Stratakis, Jesse A Goodrich, Haotian Wu, Shelley H Liu, Hongxu Wang, Emily Beglarian, Scott M Bartell, Sandrah Proctor Eckel and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Yijie LiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Brittney O BaumertDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Nikos StratakisBarcelona Institute of Global Health, Barcelona, Spain.
Jesse A GoodrichDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Haotian WuDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA.
Shelley H LiuDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hongxu WangDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Emily BeglarianDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Scott M BartellDepartment of Environmental and Occupational Health and Department of Epidemiology and Biostatistics, University of California, Irvine, CA, USA.
Sandrah Proctor EckelDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Douglas WalkerGangarosa Department of Environmental Health, Rollins School of Public Health, 1518 Clifton Road, NE, Atlanta, GA, USA.
Damaskini ValviDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michele Andrea La MerrillDepartment of Environmental Toxicology, University of California, Davis, CA, USA.
Thomas H IngeDepartment of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Todd JenkinsCincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA.
Justin R RyderDepartment of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Stephanie SisleyDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Rohit KohliDivision of Gastroenterology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Stavra A XanthakosDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Marina VafeiadiDepartment of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.
Aikaterini MargetakiDepartment of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.
Theano RoumeliotakiBarcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Department of Social Medicine, School of Medicine, University of Crete, Greece.
Max AungDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Rob McConnellDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Andrea BaccarelliHarvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
David ContiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lida ChatziDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: chatzi@usc.edu.

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Paul Marjoram · 2016 to 2026
$25.5M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Chris Gennings · 2014 to 2026
$21.3M
Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Research ProjectUM1DK072493 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI INGE, THOMAS HARRIS · 2011 to 2020
$10.5M
Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) renewalUM1DK095710 · NIDDK · UNIVERSITY OF CINCINNATI · PI JENKINS, TODD M, XIE, CHANGCHUN · 2011 to 2020
$9.4M
Untargeted Analysis ResourceU2CES030859 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ARORA, MANISH · 2019 to 2025
$8.2M
Training Grant in Genomic Analysis and InterpretationT32ES013678 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GAUDERMAN, WILLIAM JAMES, MCCONNELL, ROB S · 2006 to 2023
$5.6M
Translation CoreP2CES033433 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jill E Johnston, Elizabeth Mary Kamai · 2022 to 2026
$4.9M
Effects of DDE exposure on adipose tissue function, weight loss and metabolic improvement after bariatric surgery: A new paradigm for study of lipophilic chemicalsR01ES030364 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHATZI, VAIA LIDA · 2020 to 2024
$3.2M
Perfluoroalkyl substances and incident type 2 diabetes in a US population: A metabolome-genome investigationR01ES033688 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Damaskini Valvi · 2022 to 2026
$3.2M
Environmental Chemical Exposures and Longitudinal Changes of Glucose Metabolism, Insulin Sensitivity and B Cell Function in YouthR01ES029944 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHATZI, VAIA LIDA · 2019 to 2023
$3.1M
Brain VDR Regulate Glucose BalanceR01DK128117 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Stephanie Renee Sisley · 2022 to 2026
$2.5M
NCI NIH HHS P01 CA196569NHGRI NIH HHS U01 HG013288NICHD NIH HHS K25 HD104918NIDDK NIH HHS R01 DK128117NIDDK NIH HHS UM1 DK072493NIDDK NIH HHS UM1 DK095710NIEHS NIH HHS P2C ES033433NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES029944NIEHS NIH HHS R01 ES030364NIEHS NIH HHS R01 ES030691NIEHS NIH HHS R01 ES032831NIEHS NIH HHS R01 ES033688NIEHS NIH HHS R03 ES033374NIEHS NIH HHS R21 ES029681NIEHS NIH HHS R21 ES035148NIEHS NIH HHS T32 ES013678NIEHS NIH HHS U2C ES030859
6 · The paper itself

Abstract

backgroundPer- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment and can accumulate in humans, leading to adverse health effects. MicroRNAs (miRNAs) are emerging biomarkers that can advance the understanding of the mechanisms of PFAS effects on human health. However, little is known about the associations between PFAS exposures and miRNA alterations in humans.

objectiveTo investigate associations between PFAS concentrations and miRNA levels in children.

methodsData from two distinct cohorts were utilized: 176 participants (average age 17.1 years; 75.6% female) from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort in the United States, and 64 participants (average age 6.5 years, 39.1% female) from the Rhea study, a mother-child cohort in Greece. PFAS concentrations and miRNA levels were assessed in plasma samples from both studies. Associations between individual PFAS and plasma miRNA levels were examined after adjusting for covariates. Additionally, the cumulative effects of PFAS mixtures were evaluated using an exposure burden score. Ingenuity Pathways Analysis was employed to identify potential disease functions of PFAS-associated miRNAs.

resultsPlasma PFAS concentrations were associated with alterations in 475 miRNAs in the Teen-LABs study and 5 miRNAs in the Rhea study (FDR p < 0.1). Specifically, plasma PFAS concentrations were consistently associated with decreased levels of miR-148b-3p and miR-29a-3p in both cohorts. Pathway analysis indicated that PFAS-related miRNAs were linked to numerous chronic disease pathways, including cardiovascular diseases, inflammatory conditions, and carcinogenesis.

conclusionThrough miRNA screenings in two independent cohorts, this study identified both known and novel miRNAs associated with PFAS exposure in children. Pathway analysis revealed the involvement of these miRNAs in several cancer and inflammation-related pathways. Further studies are warranted to enhance our understanding of the relationships between PFAS exposure and disease risks, with miRNA emerging as potential biomarkers and/or mediators in these complex pathways.

Indexed as

Environmental ExposureEnvironmental PollutantsFluorocarbonsMicroRNAsAdolescentBiomarkersChildCohort StudiesFemaleGreeceHumansLongitudinal StudiesMaleUnited StatesBiomarkersEnvironmental PollutantsFluorocarbonsMicroRNAsCarcinogenesisMicroRNAPer- and polyfluoroalkyl substancesPersistent organic pollutantsTranscriptomics

Identifiers

PMID38936497
PMCPMC11847561

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.