Evidence map›Paper›PMID 38935914›Full record

SynthesisMedical mycology2024

Fusarium species,Scedosporium species, and Lomentospora prolificans: A systematic review to inform the World Health Organization priority list of fungal pathogens.

Tina Marinelli, Hannah Yejin Kim, Catriona L Halliday, Katherine Garnham, Olivia Bupha-Intr, Aiken Dao, Arthur J Morris, Ana Alastruey-Izquierdo, Arnaldo Colombo, Volker Rickerts and 19 more

Abstract readSystematic Review
In one paragraph

Synthesis in Medical mycology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. A review of bloodstream infections-pathogens, pathogenesis, diagnostic strategies, treatment methods-challenges and future aspects.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  6. A review of bloodstream infections-pathogens, pathogenesis, diagnostic strategies, treatment methods-challenges and future aspects.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Dematiaceous Molds.Infectious disease clinics of North America · 2025
    Review
  12. High azole MICs in Fusarium spp.: a key factor in treatment decisions for cancer patients?Revista do Instituto de Medicina Tropical de Sao Paulo · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Tina MarinelliDepartment of Infectious Diseases and Microbiology, Royal Prince Alfred Hospital, Sydney, Australia.ORCID 0000-0003-0404-787X
Hannah Yejin KimSydney Infectious Diseases Institute (Sydney ID), The University of Sydney, New South Wales, Australia.ORCID 0000-0002-1808-5036
Catriona L HallidayCentre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, Westmead, New South Wales, Australia.ORCID 0000-0002-0301-7110
Katherine GarnhamDepartment of Infectious Diseases and Microbiology, Gold Coast University Hospital, Southport, Queensland, Australia.ORCID 0000-0003-1607-0698
Olivia Bupha-IntrDepartment of Infection Services, Wellington Regional Hospital, Wellington, New Zealand.
Aiken DaoSydney Infectious Diseases Institute (Sydney ID), The University of Sydney, New South Wales, Australia.ORCID 0000-0002-0631-2975
Arthur J MorrisDepartment of Clinical Microbiology, Auckland City Hospital, Grafton, Auckland, New Zealand.
Ana Alastruey-IzquierdoMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.ORCID 0000-0001-8651-4405
Arnaldo ColomboDepartamento de Medicina, Division of Infectious Diseases, Hospital São Paulo, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.ORCID 0000-0003-0793-8491
Volker RickertsRobert Koch Institute Berlin, Berlin, Germany.ORCID 0000-0002-6154-4920
John PerfectDivision of Infectious Diseases and International Health, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-0019-8638
David W DenningManchester Fungal Infection Group, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.ORCID 0000-0001-5626-2251
Marcio NucciUniversidade Federal do Rio de Janeiro and Grupo Oncoclinicas, Rio de Janeiro, Brazil.ORCID 0000-0003-4867-0014
Raph L HamersOxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.ORCID 0000-0002-5007-7896
Alessandro CassiniInfectious Diseases Service, Lausanne University Hospital, Lausanne, Switzerland.ORCID 0000-0002-7973-6445
Rita OladeleDepartment of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Lagos, Nigeria.ORCID 0000-0003-1488-3345
Tania C SorrellSydney Infectious Diseases Institute (Sydney ID), The University of Sydney, New South Wales, Australia.ORCID 0000-0001-9460-0960
Pilar Ramon-PardoDepartment of Communicable Diseases Prevention, Control and Elimination, Pan American Health Organization, Washington, District of Columbia, USA.ORCID 0000-0002-4862-2568
Terence FusireSouth East Asia Region Office, World Health Organization, New Delhi, India.ORCID 0000-0001-6957-7949
Tom M ChillerMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0002-2251-8033
Retno WahyuningsihDepartment of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.ORCID 0000-0002-3294-5792
Agustina ForastieroDepartment of Communicable Diseases Prevention, Control and Elimination, Pan American Health Organization, Washington, District of Columbia, USA.
Adi Al-NuseiratDepartment of Health Systems, World Health Organization, Regional Office of the Eastern Mediterranean, Cairo, Egypt.ORCID 0000-0002-7259-7577
Peter BeyerGlobal Antibiotics Research and Development Partnership, Drugs for Neglected Diseases Initiative, Geneva, Switzerland.ORCID 0000-0003-4168-8668
Valeria GiganteAMR Division, World Health Organization, Geneva, Switzerland.ORCID 0000-0003-2496-6048
Justin BeardsleySydney Infectious Diseases Institute (Sydney ID), The University of Sydney, New South Wales, Australia.ORCID 0000-0003-1978-1559
Hatim SatiAMR Division, World Health Organization, Geneva, Switzerland.ORCID 0000-0003-2358-0522
Jan-Willem AlffenaarSydney Infectious Diseases Institute (Sydney ID), The University of Sydney, New South Wales, Australia.ORCID 0000-0001-6703-0288
C Orla MorrisseyDepartment of Infectious Diseases, Alfred Health and Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-9970-9575

Funding

WHOWorld Health Organization 001
6 · The paper itself

Abstract

Recognizing the growing global burden of fungal infections, the World Health Organization established a process to develop a priority list of fungal pathogens (FPPL). In this systematic review, we aimed to evaluate the epidemiology and impact of infections caused by Fusarium spp., Scedosporium spp., and Lomentospora prolificans to inform the first FPPL. PubMed and Web of Sciences databases were searched to identify studies published between January 1, 2011 and February 23, 2021, reporting on mortality, complications and sequelae, antifungal susceptibility, preventability, annual incidence, and trends. Overall, 20, 11, and 9 articles were included for Fusarium spp., Scedosporium spp., and L. prolificans, respectively. Mortality rates were high in those with invasive fusariosis, scedosporiosis, and lomentosporiosis (42.9%-66.7%, 42.4%-46.9%, and 50.0%-71.4%, respectively). Antifungal susceptibility data, based on small isolate numbers, showed high minimum inhibitory concentrations (MIC)/minimum effective concentrations for most currently available antifungal agents. The median/mode MIC for itraconazole and isavuconazole were ≥16 mg/l for all three pathogens. Based on limited data, these fungi are emerging. Invasive fusariosis increased from 0.08 cases/100 000 admissions to 0.22 cases/100 000 admissions over the time periods of 2000-2009 and 2010-2015, respectively, and in lung transplant recipients, Scedosporium spp. and L. prolificans were only detected from 2014 onwards. Global surveillance to better delineate antifungal susceptibility, risk factors, sequelae, and outcomes is required.

Indexed as

Antifungal AgentsFusariumMicrobial Sensitivity TestsScedosporiumAscomycotaFusariosisHumansInvasive Fungal InfectionsMycosesWorld Health OrganizationAntifungal Agentsantifungal resistanceepidemiologyfungemiaFusariuminvasive fungal diseaseLomentospora prolificansmortalityScedosporium apiospermum

Identifiers

PMID38935914
PMCPMC11210614

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.