ArticleAmerican journal of respiratory and critical care medicine2024
Increased Muc5AC and Decreased Ciliated Cells in Severe Asthma Partially Restored by Inhibition of IL-4Rα Receptor.
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In one paragraph
Article in American journal of respiratory and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review.Respiratory research · 2026Pooled it
- Targeting Tight Junction Proteins to Restore Airway Epithelial Barrier Function in Asthma.Current allergy and asthma reports · 2026Review
- Review
- Review
- Necroptosis in asthma: a critical driver of immune dysregulation and airway remodeling.Frontiers in immunology · 2026Review
- The primary cilium as a compartmentalized signaling hub in tissue immunity and homeostasis.Frontiers in cell and developmental biology · 2026Review
- Pulmonary neuroendocrine cells in pediatric asthma and bronchopulmonary dysplasia: neuroimmune-developmental mechanisms and translational implications.Frontiers in medicine · 2026Review
- CPA3 drives the development of asthma by promoting the activation of the JAK/STAT6 pathway.Respiratory research · 2025Article
- Next Decade Research in Asthma: Broad Omics-Based Exploration Versus Targeted Airway Epithelium Studies.Journal of clinical medicine · 2025Review
- Machine learning reveals limited predictive value of clinical factors for asthma exacerbations.Scientific reports · 2025Article
- STAT3-Dependent Regulation of CFTR and Ciliogenesis Is Essential for Mucociliary Clearance and Innate Airway Defense in Hyper-IgE Syndrome.American journal of respiratory and critical care medicine · 2025Article
- The immunology of asthma.Nature immunology · 2025Review
- Evaluation of Small Airways Dysfunction With Dupilumab Using Airway Oscillometry in Uncontrolled Severe Asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Innate Immunity and Asthma Exacerbations: Insights From Human Models.Immunological reviews · 2025Review
- Established and Emerging Biological Therapies for the Treatment of Comorbid Asthma and Chronic Obstructive Pulmonary Disease.Journal of inflammation research · 2025Review
- Unlocking lung regeneration: insights into progenitor cell dynamics and metabolic control.Cell regeneration (London, England) · 2024Review
- Breaking up Mucus Plugs in Asthma.American journal of respiratory and critical care medicine · 2024Article
Corrections and comments
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Authors and funding
19 authors.
Jonathan BoomerDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Jiwoong ChoiDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Alexander AlsupDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Mary Clare McGregorDivision of Pulmonary and Critical Care Medicine and.
Julia LieuDivision of Pulmonary and Critical Care Medicine and.
Cooper JohnsonDivision of Pulmonary and Critical Care Medicine and.
Chase HallDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Xiaosong ShiDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Taewon KimDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Charles GossDivision of Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Daphne LewDivision of Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Stephanie ChristensenDivision of Pulmonary, Allergy, and Critical Care, University of California San Francisco, San Francisco, California.
Prescott WoodruffDivision of Pulmonary, Allergy, and Critical Care, University of California San Francisco, San Francisco, California.
Annette HastieSection of Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, North Carolina.ORCID 0000-0001-6607-7797
David MaugerDivision of Statistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Hershey, Pennsylvania.
Sally E WenzelDepartment of Environmental and Occupational Health, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and.ORCID 0000-0002-4242-0164
Eric HoffmanDepartments of Radiology, Biomedical Engineering and Internal Medicine, University of Iowa, Iowa City, Iowa.ORCID 0000-0001-8456-9437
Kenneth B SchechtmanDivision of Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Mario CastroDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0001-6328-8994
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MViral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0MRADx-UP: Improving the Response of Local Urban and Rural Communities to Disparities in Covid-19 TestingUL1TR002366 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Mario Castro, JAMES STEVEN LEEDER · 2017 to 2026
$44.3MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MUnderstanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2008 to 2026
$41.1MPulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MRole of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2012 to 2023
$23.3MRapid saliva antigen test for SARS-CoV-2 detectionU01HL146002 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ARONICA, MARK A, CASTRO, MARIO · 2019 to 2023
$17.3MWashington University Institute of Clinical and Translational Sciences (KL2) KL2TR002346 · NCATS · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 2017 to 2026
$14.0MWashington University Institute of Clinical and Translational Sciences (TL1)TL1TR002344 · NCATS · WASHINGTON UNIVERSITY · PI Jay F. Piccirillo · 2017 to 2026
$8.5MSevere Asthma Research Program (SARP)-Washington UniversityU10HL109257 · NHLBI · WASHINGTON UNIVERSITY · PI CASTRO, MARIO · 2011 to 2016
$3.8MNCATS NIH HHS KL2 TR002346NCATS NIH HHS TL1 TR002344NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1TR000448NCATS NIH HHS UL1 TR002345NCATS NIH HHS UL1TR002345NCATS NIH HHS UL1 TR002366NCATS NIH HHS UL1TR002366NCI NIH HHS P30 CA086862NHLBI NIH HHS P01 HL107202NHLBI NIH HHS U01 HL146002NHLBI NIH HHS U01HL146002NHLBI NIH HHS U10 HL109257NIAID NIH HHS U19 AI077439NIEHS NIH HHS P30 ES005605Regeneron Pharmaceuticals KL2TR002346Regeneron Pharmaceuticals R668-AAS-1979Regeneron Pharmaceuticals TL1TR002344
Abstract
PubMed holds no abstract for this paper.
Indexed as
Airway RemodelingAntibodies, Monoclonal, HumanizedAsthmaCiliaInterleukin-13Interleukin-4 Receptor alpha SubunitMucin 5ACAdultEpithelial CellsFemaleGoblet CellsHumansMaleMiddle AgedRespiratory MucosaAntibodies, Monoclonal, HumanizeddupilumabIL4R protein, humanInterleukin-13Interleukin-4 Receptor alpha SubunitMUC5AC protein, humanMucin 5ACairway remodelingdupilumabsevere asthma
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Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.