ArticleAge and ageing2024
Development and validation of a frailty index for use in the osteoarthritis initiative.
Article in Age and ageing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Metabolic score for visceral fat as a superior predictor of frailty in overweight and obese adults: a cross-sectional NHANES analysis (2007-2020).Diabetology & metabolic syndrome · 2025Article
- Frailty moderates the relation between moderate-to-vigorous physical activity & stationary time with knee osteoarthritis symptoms.The Journal of frailty & aging · 2025Observational
- The relation between radiographic knee osteoarthritis severity and pain is stronger among more frail people.Clinical rheumatology · 2025Article
- Article
- Global, regional, and national burdens of osteoarthritis from 1990 to 2021: findings from the 2021 global burden of disease study.Frontiers in medicine · 2024Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe Osteoarthritis Initiative (OAI) evaluates the development and progression of osteoarthritis. Frailty captures the heterogeneity in aging. Use of this resource-intensive dataset to answer aging-related research questions could be enhanced by a frailty measure.
objectiveTo: (i) develop a deficit accumulation frailty index (FI) for the OAI; (ii) examine its relationship with age and compare between sexes, (iii) validate the FI versus all-cause mortality and (iv) compare this association with mortality with a modified frailty phenotype.
designOAI cohort study.
settingNorth America. SUBJECTS: An FI was determined for 4,755/4,796 and 4,149/4,796 who had a valid FI and frailty phenotype.
methodsFifty-nine-variables were screened for inclusion. Multivariate Cox regression evaluated the impact of FI or phenotype on all-cause mortality at follow-up (up to 146 months), controlling for age and sex.
resultsThirty-one items were included. FI scores (0.16 ± 0.09) were higher in older adults and among females (both, P < 0.001). By follow-up, 264 people had died (6.4%). Older age, being male, and greater FI were associated with a higher risk of all-cause mortality (all, P < 0.001). The model including FI was a better fit than the model including the phenotype (AIC: 4,167 vs. 4,178) and was a better predictor of all-cause mortality than the phenotype with an area under receiver operating characteristic curve: 0.652 vs. 0.581.
conclusionWe developed an FI using the OAI and validated it in relation to all-cause mortality. The FI may be used to study aging on clinical, functional and structural aspects of osteoarthritis included in the OAI.
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