Evidence map›Paper›PMID 38935506›Full record

ArticleCell reports2024

The exocyst subunit EXOC2 regulates the toxicity of expanded GGGGCC repeats in C9ORF72-ALS/FTD.

Dilara O Halim, Gopinath Krishnan, Evan P Hass, Soojin Lee, Mamta Verma, Sandra Almeida, Yuanzheng Gu, Deborah Y Kwon, Thomas G Fazzio, Fen-Biao Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dilara O HalimFrontotemporal Dementia Research Center, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Gopinath KrishnanFrontotemporal Dementia Research Center, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Evan P HassDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Soojin LeeFrontotemporal Dementia Research Center, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Mamta VermaFrontotemporal Dementia Research Center, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Sandra AlmeidaDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Yuanzheng GuNeuromuscular & Muscle Disorders, Biogen, Cambridge, MA 02142, USA.
Deborah Y KwonNeuromuscular & Muscle Disorders, Biogen, Cambridge, MA 02142, USA.
Thomas G FazzioDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Fen-Biao GaoFrontotemporal Dementia Research Center, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA. Electronic address: fen-biao.gao@umassmed.edu.

Funding

Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1R37NS057553 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2018 to 2024
$4.3M
Understanding Frontotemporal Dementia Using Drosophila and iPSC ModelsR01NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Fen-Biao Gao · 2017 to 2026
$3.6M
Characterization of the gene regulatory network governing the first cell fate decision in mammalian embryonic developmentR01HD104971 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Thomas G Fazzio, Juan Ignacio Fuxman Bass · 2022 to 2026
$2.6M
Understanding Frontotemporal Dementia Using Drosophila and iPSC ModelsRF1NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2022 to 2022
$2.1M
Investigating Translational De-repression as a Mechanism to Increase Progranulin Levels in iPSC-derived Patient NeuronsR21NS112766 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ALMEIDA, SANDRA · 2019 to 2019
$461k
Characterization of TASK-1 Modulation of Dipeptide Repeat Protein-Mediated Toxicity in iPSC-derived C9ORF72 Patient Neurons.R21NS119952 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ALMEIDA, SANDRA · 2020 to 2020
$461k
NICHD NIH HHS R01 HD104971NINDS NIH HHS R01 NS101986NINDS NIH HHS R21 NS112766NINDS NIH HHS R21 NS119952NINDS NIH HHS R37 NS057553NINDS NIH HHS RF1 NS101986
6 · The paper itself

Abstract

GGGGCC (G

Indexed as

Amyotrophic Lateral SclerosisC9orf72 ProteinDNA Repeat ExpansionFrontotemporal DementiaInduced Pluripotent Stem CellsHumansMotor NeuronsC9orf72 ProteinC9orf72 protein, humanALSASOC9ORF72CP: Cell biologyCP: NeuroscienceDPRexocystFTDiPSCneurodegenerationneuronpoly(GR)

Identifiers

PMID38935506
PMCPMC11299523

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.