Evidence map›Paper›PMID 38935303›Full record

ArticleMolecular diversity2025

Discovery of a novel pyrido[1,2-a]thiazolo[5,4-d]pyrimidinone derivatives with excellent potency against acetylcholinesterase.

Yan Zeng, Zhifeng Chen, Zhiyong Yang, Fangxue Yuan, Lifei Nie, Chao Niu

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yan ZengXinjiang Key Laboratory of Coal Mine Disaster Intelligent Prevention and Emergency Response, Xinjiang Institute of Engineering, Urumqi, 830023, China.
Zhifeng ChenXinjiang Key Laboratory of Coal Mine Disaster Intelligent Prevention and Emergency Response, Xinjiang Institute of Engineering, Urumqi, 830023, China.
Zhiyong YangXinjiang Key Laboratory of Coal Mine Disaster Intelligent Prevention and Emergency Response, Xinjiang Institute of Engineering, Urumqi, 830023, China.
Fangxue YuanXinjiang Key Laboratory of Coal Mine Disaster Intelligent Prevention and Emergency Response, Xinjiang Institute of Engineering, Urumqi, 830023, China.
Lifei NieState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, CAS Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China. nielf@ms.xjb.ac.cn.
Chao NiuState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, CAS Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China. niuchao@ms.xjb.ac.cn.

Funding

Special Training Program of Natural Science Foundation of Xinjiang Autonomous Region 2022D03018the Natural Science Foundation of Xinjiang Uygur Autonomous Region 2022D01A339the Natural Science Foundation of Xinjiang Uygur Autonomous Region 2022D01A340the Xinjiang Uygur Autonomous Region"Tianchi Talent"lntroduction Program 2024XGYTCYC07West Light Foundation of the Chinese Academy of Sciences 2023-XBQNXZ-009
6 · The paper itself

Abstract

As mimetic compounds of the natural alkaloid mackinazolinone, forty pyrido[1,2-a]thiazolo[5,4-d] pyrimidinone were designed and synthesized from a bioisosterism approach. The structure of these compounds was confirmed through analysis using

Indexed as

AcetylcholinesteraseCholinesterase InhibitorsDrug DiscoveryPyrimidinonesThiazolesHumansMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity RelationshipAcetylcholinesteraseCholinesterase InhibitorsPyrimidinonesThiazolesAcetylcholinesteraseBioisosterismMolecular dockingMolecular dynamicsThiazolo[5,4-d]pyrimidinone

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.