Evidence map›Paper›PMID 38935278›Full record

ArticleNeuromolecular medicine2024

Association of NID2 SNPs with Glioma Risk and Prognosis in the Chinese Population.

Jie Hao, Congmei Huang, Weiwei Zhao, Lin Zhao, Xiuxia Hu, WenJie Zhang, Le Guo, Xia Dou, Tianbo Jin, Mingjun Hu

Abstract read
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In one paragraph

Article in Neuromolecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jie HaoCollege of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China.
Congmei HuangDepartment of Gynaecology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Weiwei ZhaoCollege of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China.
Lin ZhaoCollege of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China.
Xiuxia HuCollege of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China.
WenJie ZhangCollege of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China.
Le GuoCollege of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China.
Xia DouCollege of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China.
Tianbo JinCollege of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China. jintb@nwu.edu.cn.
Mingjun HuCollege of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China. humingjun2020@163.com.

Funding

Scientific Research Project of Xi'an Municipal Health Commission 2021ms04Shaanxi Province Key Research and Development Program 2022SF-582Xi'an Science and Technology Plan Project 21YXYJ0074
6 · The paper itself

Abstract

Glioma is the most common primary intracranial tumor with high mortality and poor prognosis. The purpose of this study was to investigate how single-nucleotide polymorphisms (SNPs) of the NID2 gene affect glioma risk and prognosis. Four candidate SNPs of NID2 in 529 glioma patients and 478 healthy controls were successfully genotyped by Agena MassARRAY mass spectrometer. Logistic regression was utilized to assess the associations between NID2 SNPs and glioma risk under different genetic models. Furthermore, the relationship between risk-related SNPs in NID2 and the prognosis of glioma patients was explored through Kaplan-Meier (KM) survival curve and Cox proportional hazard regression analysis. The results showed that rs11846847 (OR 1.24, p = 0.017) and rs1874569 (OR 1.22, p = 0.026) were significantly associated with an increased risk of glioma, and rs11846847 also had a risk-increasing effect on glioma in participants ≤ 40 years old. The interaction model of rs11846847 and rs1874569 could be more suitable for forecasting glioma risk. We also discovered a significant association between rs1874569 and poor prognosis in glioma patients (HR 1.32, p = 0.039) and especially CC genotype was relevant to shorter overall survival (OS) and progression-free survival (PFS) in patients with high-grade glioma. Additionally, the study demonstrated that gross total resection or chemotherapy improve glioma prognosis in the Chinese Han population. This study is the first to provide evidence for the association of NID2 SNPs with glioma risk and prognosis, suggesting that NID2 variants might be potential factors for glioma.

Indexed as

Brain NeoplasmsCalcium-Binding ProteinsGenetic Predisposition to DiseaseGliomaAdultCase-Control StudiesCell Adhesion MoleculesChinaEast Asian PeopleFemaleGenotypeHumansKaplan-Meier EstimateMaleMiddle AgedPolymorphism, Single NucleotideCalcium-Binding ProteinsCell Adhesion MoleculesNID2 protein, humanGliomaNID2PrognosisRiskSingle-nucleotide polymorphisms (SNPs)

Identifiers

PMID38935278

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