Evidence map›Paper›PMID 38935127›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2024

Mitigating effect of gallic acid on zinc oxide nanoparticles and arsenic trioxide-induced spermatogenesis suppression, testicular injury, hormonal imbalance, and immunohistochemical changes in rats.

Amany Behairy, Mohamed M M Hashem, Khaled Abo-El-Sooud, Abeer E El-Metwally, Ahmed M Soliman, Samar M Mouneir, Bayan A Hassan, Yasmina M Abd-Elhakim

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amany BehairyDepartment of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt.
Mohamed M M HashemDepartment of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
Khaled Abo-El-SooudDepartment of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
Abeer E El-MetwallyPathology Department, Animal Reproduction Research Institute, Giza, 3514805, Egypt.
Ahmed M SolimanDepartment of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
Samar M MouneirDepartment of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
Bayan A HassanPharmacology Department, Faculty of Pharmacy, Future University, Cairo, 11835, Egypt.
Yasmina M Abd-ElhakimDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt. yasmina_forensic@hotmail.com.

Funding

Cairo univeristy Cairo university projects-12-2021
6 · The paper itself

Abstract

The current study compared the effects of incorporated exposure to arsenic trioxide (As) and zinc oxide nanoparticles (ZnONPs) on male reproductive hormones, oxidative stress, and inflammatory biomarkers in adult rats to each metal alone. A defensive trial with gallic acid (GA) has also been studied. A total of 60 adult male Sprague Dawley rats were categorized into six groups: control, GA (20 mg/kg), ZnONPs (100 mg/kg), As (8 mg/kg), ZnONPs with As, and GA concurrently with ZnONPs and As at the same previous doses. The regimens were applied for 60 days in sequence. Current findings showed significant weight loss in all study groups, with testicular weights significantly decreased in the As and combined groups. Testosterone, follicular stimulating hormone, and luteinizing hormone serum levels were also considerably reduced, while serum levels of estradiol increased. Inducible nitric oxide synthase (iNOS) immunoexpression was significantly upregulated while proliferating cell nuclear antigen (PCNA) was downregulated. Moreover, there was a significant elevation of testicular malondialdehyde, reduction of testicular superoxide dismutase, and glutathione peroxidase with disruptive testes, prostate glands, and seminal vesicle alterations in all experimental groups with marked changes in the combined group. Additionally, the present results revealed the protective effects of GA on ZnONPs and As adverse alterations in rats. GA enhanced sperm picture, oxidant status, and hormonal profile. Also, it modulates iNOS and PCNA immunoexpression and recovers the histoarchitecture of the testes, prostate glands, and seminal vesicles. Ultimately, GA may be a promising safeguarding agent against ZnONPs and As-induced disturbances to reproductive parameters.

Indexed as

Arsenic TrioxideGallic AcidRats, Sprague-DawleySpermatogenesisTestisZinc OxideAnimalsAntioxidantsFollicle Stimulating HormoneLuteinizing HormoneMaleNanoparticlesNitric Oxide Synthase Type IIOxidative StressProliferating Cell Nuclear AntigenRatsAntioxidantsArsenic TrioxideFollicle Stimulating HormoneGallic AcidLuteinizing HormoneNitric Oxide Synthase Type IIProliferating Cell Nuclear AntigenTestosteroneZinc OxideArsenic trioxideGallic acidInducible nitric oxide synthaseProliferating cell nuclear antigenTestisZinc oxide nanoparticles

Identifiers

PMID38935127
PMCPMC11582332

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.