Evidence map›Paper›PMID 38934919›Full record

ArticleBehavioral neuroscience2024

Fear attenuation collaborations to optimize translation.

Marie-H Monfils, Hongjoo J Lee, Marissa Raskin, Yael Niv, Jason Shumake, Michael J Telch, Jasper A J Smits, Michael W Otto

Abstract read
In one paragraph

Article in Behavioral neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marie-H MonfilsDepartment of Psychology, University of Texas, Austin.ORCID 0000-0001-8971-6651
Hongjoo J LeeDepartment of Psychology, University of Texas, Austin.ORCID 0000-0002-0110-5432
Marissa RaskinInstitute for Neuroscience, University of Texas, Austin.
Yael NivDepartment of Psychology, Princeton University.
Jason ShumakeDepartment of Psychology, University of Texas, Austin.
Michael J TelchDepartment of Psychology, University of Texas, Austin.ORCID 0000-0003-3444-8500
Jasper A J SmitsDepartment of Psychology, University of Texas, Austin.ORCID 0000-0003-1633-9693
Michael W OttoDepartment of Psychological and Brain Sciences, Boston University.

Funding

1/2: CO2 Reactivity as a Biomarker of Non-response to Exposure-based TherapyR01MH125951 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI Marie H. Monfils, Jasper Smits · 2022 to 2026
$3.6M
2/2-CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based TherapyR01MH125949 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Michael W. Otto · 2022 to 2026
$2.8M
NIMH NIH HHS R01 MH125949NIMH NIH HHS R01 MH125951
6 · The paper itself

Abstract

Here, we describe the efforts we dedicated to the challenge of modifying entrenched emotionally laden memories. In recent years, through a number of collaborations and using a combination of behavioral, molecular, and computational approaches, we: (a) developed novel approaches to fear attenuation that engage mechanisms that differ from those engaged during extinction (Monfils), (b) examined whether our approaches can generalize to other reinforcers (Lee, Gonzales, Chaudhri, Cofresi, and Monfils), (c) derived principled explanations for the differential outcomes of our approaches (Niv, Gershman, Song, and Monfils), (d) developed better assessment metrics to evaluate outcome success (Shumake and Monfils), (e) identified biomarkers that can explain significant variance in our outcomes of interest (Shumake and Monfils), and (f) developed better basic research assays and translated efforts to the clinic (Smits, Telch, Otto, Shumake, and Monfils). We briefly highlight each of these milestones and conclude with final remarks and extracted principles. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Indexed as

Extinction, PsychologicalFearAnimalsHumansTranslational Research, Biomedical

Identifiers

PMID38934919
PMCPMC11624513

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.