Evidence map›Paper›PMID 38934412›Full record

ArticleJournal of animal science2024

Pregnancy risk in beef and dairy cows after supplementing semen with transforming growth factor beta-1 at the time of artificial insemination.

Katelyn L M Fritsche, Jason K Ahola, Pablo J Pinedo, George E Seidel, Ryan D Rhoades, Jeffrey S Stevenson, K C Olson, John R Jaeger, David M Grieger, John J Bromfield

Abstract read
In one paragraph

Article in Journal of animal science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katelyn L M FritscheDepartment of Animal Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Jason K AholaDepartment of Animal Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Pablo J PinedoDepartment of Animal Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0001-7111-3377
George E SeidelAnimal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, CO 80523, USA.
Ryan D RhoadesDepartment of Animal Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Jeffrey S StevensonDepartment of Animal Sciences and Industry, Kansas State University, Manhattan, KS 66506, USA.
K C OlsonDepartment of Animal Sciences and Industry, Kansas State University, Manhattan, KS 66506, USA.
John R JaegerDepartment of Animal Sciences and Industry, Kansas State University, Manhattan, KS 66506, USA.
David M GriegerDepartment of Animal Sciences and Industry, Kansas State University, Manhattan, KS 66506, USA.
John J BromfieldDepartment of Animal Sciences, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0001-5438-2137

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our objective was to determine if the addition of a concentrated human recombinant transforming growth factor beta-1 (TGF) to bovine semen at the time of AI would result in increased risk of pregnancy in beef and dairy cows. Suckled beef cows (n = 1,132) in 11 herds across 2 states and lactating dairy cows (n = 2,208) in one organic-certified herd were enrolled. Beef cows received fixed-time AI (FTAI) following a 7 d CO-Synch + controlled internal drug release estrous synchronization protocol. Dairy cows were inseminated following observation of natural estrus expression. Cows received either no treatment as a control (CON) or 10 ng of TGF in 10 μL added through the cut-end of a thawed straw of semen immediately prior to AI. At the time of FTAI of beef cows, the mean ± SD age was 5.0 ± 2.4 yr, BCS was 5.3 ± 0.7, and days postpartum was 78.2 ± 15.5 d. The overall pregnancy risk (PR) in beef cows was 55.2% to AI and 90.5% season-long. PR in beef cows was not affected (P = 0.27) by the addition of TGF (53.1% vs. 58.1%). Furthermore, there was no difference (P = 0.88) for season-long PR in beef cows that received TGF (91.2% vs. 91.5%). At the time of insemination of dairy cows, the mean ± SD lactation was 3.0 ± 1.3 lactations, BCS was 2.9 ± 0.3, days in milk was 115.6 ± 56.6 d, and cows had received 2.4 ± 1.5 inseminations/cow. The overall pregnancy risk to AI in dairy cows was 23.1%. PR to AI for dairy cows was not affected (P = 0.32) by addition of TGF (22.0% vs. 23.8%). In conclusion, PR to AI was not affected by addition of TGF to thawed semen immediately prior to AI in beef or dairy cows.

Indexed as

Insemination, ArtificialSemenTransforming Growth Factor beta1AnimalsCattleEstrus SynchronizationFemaleLactationMalePregnancyTransforming Growth Factor beta1artificial inseminationbeef cowsorganic dairy cowsseminal plasmatransforming growth factor beta-1

Identifiers

PMID38934412
PMCPMC11245693

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.