ArticleFrontiers in nutrition2024
Optimal extraction conditions and quantification of lignan phytoestrogens in cereal grains using targeted LC-MS/MS.
Article in Frontiers in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Optimization of Polyphenol Extraction Process from Yunnan-Grown Olives and Analysis of Taste Capacity Using Response Surface Methodology.Molecules (Basel, Switzerland) · 2026Article
- A Comparison of the Occurrence of Bioactive Compounds in the Grain of DifferentMolecules (Basel, Switzerland) · 2026Review
- Molecular Mechanisms of Lignans in Lowering Blood Pressure and Anti-Obesity Effects: A Review.Foods (Basel, Switzerland) · 2026Review
- Comparison of Lignan Contents and Antioxidant Activities in Five Perilla (Preventive nutrition and food science · 2026Article
- Review
- Lignan Content and Antioxidant Capacity of Eight Sesame Varieties Cultivated in Korea.Preventive nutrition and food science · 2024Article
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Authors and funding
4 authors.
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Abstract
Lignans are phytoestrogens found in various forms such as glycosides, ester-linked oligomers, and aglycones in a variety of foods, including soy products, legumes, grains, nuts, vegetables, and fruits. This study aimed to optimize the extraction of lignans from cereal grains using response surface methodology (RSM). Lignans, including secoisolariciresinol (Seco), matairesinol (Mat), pinoresinol (Pin), lariciresinol (Lar), and syringaresinol (Syr), were quantified using high-performance liquid chromatography-tandem mass spectrometry. A Box-Behnken design was employed to determine the optimal values for three extraction parameters: temperature (X1: 20°C-60°C), methanol concentration (X2: 60%-100%), and extraction time (X3: 30-90 min). The highest lignan contents were obtained at X1 = 44.24°C, X2 = 84.64%, and X3 = 53.63 min. To apply these experimental conditions to the actual experiment, the optimal conditions were slightly adjusted to X1 = 40°C, X2 = 80%, and X3 = 60 min. The predicted results closely matched the experimental results obtained using the modified optimal extraction conditions. The highest lignan content found in barley sprouts (85.930 μg/100 g), however, most grains exhibited relatively low concentrations of lignans. These findings provide valuable insights into the lignan content of grains and contribute to the generation of reliable data in this field.
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