Evidence map›Paper›PMID 38933749›Full record

ArticleNeuro-ophthalmology (Aeolus Press)2024

Vision Threatening Raised Intracranial Pressure Associated with Recreational Nitrous Oxide Use.

Aimee Goel, Pavan S Khatkar, Jenny L Hepschke, Athanasios Zisakis, Susan P Mollan

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-ophthalmology (Aeolus Press), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. How to diagnose papilloedema.Practical neurology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aimee GoelDepartment of Neurosurgery, University Hospitals Birmingham, Birmingham, UK.ORCID https://orcid.org/0000-0002-7381-4801
Pavan S KhatkarMedical School, Imperial College London, London, UK.ORCID https://orcid.org/0009-0005-4930-5504
Jenny L HepschkeBirmingham Neuro-Ophthalmology, University Hospitals Birmingham, Birmingham, UK.ORCID https://orcid.org/0000-0001-8106-5217
Athanasios ZisakisDepartment of Neurosurgery, University Hospitals Birmingham, Birmingham, UK.ORCID https://orcid.org/0000-0002-9365-3902
Susan P MollanBirmingham Neuro-Ophthalmology, University Hospitals Birmingham, Birmingham, UK.ORCID https://orcid.org/0000-0002-6314-4437

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitrous oxide is used as an anaesthetic and analgesic agent in the medical setting and is known to cause raised intracranial pressure. The use of nitrous oxide recreationally for the drug's euphoric and relaxant properties has been linked to multiple neurological and psychiatric sequelae including neuropathy, myelopathy, and psychosis. We describe a case of a young person who declared heavy nitrous oxide use resulting in vision-threatening papilloedema secondary to raised intracranial pressure. He underwent emergency lumbar drainage alongside high-dose acetazolamide and parenteral vitamin B

Indexed as

Chronic abuseillicit druglaughing gasnitrous oxidepapilloedemaraised intracranial pressurerecreational use

Identifiers

PMID38933749
PMCPMC11197896

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.