Evidence map›Paper›PMID 38933693›Full record

ArticleFrontiers in cellular and infection microbiology2024

The multifaceted role of c-di-AMP signaling in the regulation of

Shirin Ghods, Artur Muszyński, Hyojik Yang, Ratnam S Seelan, Asal Mohammadi, Jacob S Hilson, Griffin Keiser, Frank C Nichols, Parastoo Azadi, Robert K Ernst and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Role ofAntibiotics (Basel, Switzerland) · 2026
    Review
  2. cAMP-independent Crp homolog adds to the multi-layer regulatory network inFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shirin GhodsDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY, United States.
Artur MuszyńskiComplex Carbohydrate Research Center, University of Georgia, Athens, GA, United States.
Hyojik YangDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD, United States.
Ratnam S SeelanDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY, United States.
Asal MohammadiDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY, United States.
Jacob S HilsonComplex Carbohydrate Research Center, University of Georgia, Athens, GA, United States.
Griffin KeiserComplex Carbohydrate Research Center, University of Georgia, Athens, GA, United States.
Frank C NicholsDivision of Periodontology, University of Connecticut School of Dental Medicine, Farmington, CT, United States.
Parastoo AzadiComplex Carbohydrate Research Center, University of Georgia, Athens, GA, United States.
Robert K ErnstDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD, United States.
Fata MoradaliDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY, United States.

Funding

Understanding the Host-Microbiome-Therapeutic Triad: Implications for Designing Alternative IntravaginalP20GM125504 · NIGMS · UNIVERSITY OF LOUISVILLE · PI James Tristan Collins · 2018 to 2026
$24.4M
National Glycoscience Resource- CCRC Service and Training - NGlycoR@CCRCR24GM137782 · NIGMS · UNIVERSITY OF GEORGIA · PI Parastoo Azadi · 2020 to 2026
$5.2M
MS Diagnostic Bacterial Identification LibraryR01AI147314 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI ERNST, ROBERT K, GOODLETT, DAVID ROBINSON · 2020 to 2024
$2.3M
The Control of LPS Heterogeneity and Virulence by C-di-AMP Signaling in P. gingivalisR03DE031854 · NIDCR · UNIVERSITY OF LOUISVILLE · PI MORADALI, FATA · 2022 to 2023
$469k
NIAID NIH HHS R01 AI147314NIDCR NIH HHS R03 DE031854NIGMS NIH HHS P20 GM125504NIGMS NIH HHS R24 GM137782
6 · The paper itself

Abstract

Background: This study unveils the intricate functional association between cyclic di-3',5'-adenylic acid (c-di-AMP) signaling, cellular bioenergetics, and the regulation of lipopolysaccharide (LPS) profile in Methods: We employed a comprehensive methodological approach, combining two mutants exhibiting varying levels of c-di-AMP compared to the wild type, alongside an optimized analytical methodology that combines conventional mass spectrometry techniques with a novel approach known as FLAT Results: We demonstrate that c-di-AMP acts as a metabolic nexus, connecting bioenergetic status to nuanced shifts in fatty acid and glycosyl profiles within Conclusion: The multifaceted roles of c-di-AMP in bacterial physiology are underscored, emphasizing its significance in orchestrating adaptive responses to stimuli. Furthermore, our findings illuminate the significance of LPS variations and c-di-AMP signaling in determining the biological activities and immunostimulatory potential of

Indexed as

LipopolysaccharidesPorphyromonas gingivalisSignal TransductionBacterial ProteinsDinucleoside PhosphatesEnergy MetabolismFatty AcidsGene Expression Regulation, BacterialHumansVirulence FactorsBacterial ProteinsDinucleoside PhosphatesFatty AcidsLipopolysaccharidesVirulence FactorsC-di-AMP signalingcellular bioenergeticslipopolysaccharidePorphyromonas gingivalisstructural variations

Identifiers

PMID38933693
PMCPMC11199400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.