Evidence map›Paper›PMID 38933492›Full record

ArticleMolecular therapy. Oncology2024

Efficiently targeting neuroblastoma with the combination of anti-ROR1 CAR NK cells and N-803

Yaya Chu, Gaurav Nayyar, Meijuan Tian, Dean A Lee, Mehmet F Ozkaynak, Jessica Ayala-Cuesta, Kayleigh Klose, Keira Foley, Alyssa S Mendelowitz, Wen Luo and 6 more

Erratum issuedAbstract read
In one paragraph

Article in Molecular therapy. Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Translational cancer research · 2026
    Article
  2. Article
  3. Innate immune cells in chimeric antigen receptor therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Yaya ChuDepartment of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.
Gaurav NayyarDepartment of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.
Meijuan TianDepartment of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.
Dean A LeeDepartment of Pediatric Hem/Onc/BMT, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Mehmet F OzkaynakDepartment of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.
Jessica Ayala-CuestaDepartment of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.
Kayleigh KloseDepartment of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.
Keira FoleyDepartment of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.
Alyssa S MendelowitzDepartment of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.
Wen LuoDepartment of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.
Yanling LiaoDepartment of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.
Janet AyelloDepartment of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.
Gregory K BehbehaniDepartment of Internal Medicine, Division of Hematology, the Ohio State University; Columbus, OH 43210, USA.
Stanley RiddellFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Tim CripeDepartment of Pediatric Hem/Onc/BMT, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Mitchell S CairoDepartment of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.

Funding

Project 4:Targeting M2-like Macrophages and MDSC with Myelolytic-VirotherapyU54CA232561 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI CAIRO, MITCHELL S., CRIPE, TIMOTHY P · 2019 to 2023
$12.1M
Intravascular Integrin - Mediated Steps in Breast Cancer MetastasisR01CA160461 · NCI · UNIVERSITY OF MISSOURI-COLUMBIA · PI GLINSKII, VLADISLAV V · 2013 to 2017
$1.4M
NCI NIH HHS R01 CA160461NCI NIH HHS U54 CA232561
6 · The paper itself

Abstract

The prognosis for children with recurrent and/or refractory neuroblastoma (NB) is dismal. The receptor tyrosine kinase-like orphan receptor 1 (ROR1), which is highly expressed on the surface of NB cells, provides a potential target for novel immunotherapeutics. Anti-ROR1 chimeric antigen receptor engineered

Indexed as

chimerical antigen receptorcytotoxicityexpanded natural killer cellsIL-15 superagonistMT: Regular IssueneuroblastomaROR1targeted immunotherapy

Identifiers

PMID38933492
PMCPMC11201149

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.