Evidence map›Paper›PMID 38933273›Full record

ArticleFrontiers in immunology2024

Human monoclonal antibodies protect against viral-mediated pneumococcal superinfection.

Aaron Gingerich, Lauren Mahoney, Anna L McCormick, Rose J Miller, Jarrod Mousa

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Clinical microbiology reviews · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aaron GingerichCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Lauren MahoneyCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Anna L McCormickCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Rose J MillerCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Jarrod MousaCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.

Funding

Epitope and mechanistic correlates of broadly protective human antibodies for pneumococcal infectionR01AI173084 · NIAID · UNIVERSITY OF GEORGIA · PI MOUSA, JARROD · 2023 to 2025
$2.2M
NIAID NIH HHS R01 AI173084
6 · The paper itself

Abstract

Introduction: Community-acquired pneumonia (CAP) is a global health concern, with 25% of cases attributed to Methods: We evaluated the efficacy of an anti-PhtD monoclonal antibody (mAb) cocktail therapy (PhtD3 + 7) in improving survival rates in three viral/bacterial coinfection models: IAV/ Results: The PhtD3 + 7 mAb cocktail outperformed antiviral mAbs, resulting in prolonged survival. In the IAV/ Discussion: Given the threat of antibiotic resistance, our findings highlight the potential of anti-PhtD mAb therapy as an effective option for treating viral and secondary pneumococcal coinfections.

Indexed as

Antibodies, MonoclonalCoinfectionStreptococcus pneumoniaeSuperinfectionAnimalsAntibodies, ViralDisease Models, AnimalFemaleHumansInfluenza A virusMetapneumovirusMiceMice, Inbred BALB CParamyxoviridae InfectionsPneumococcal InfectionsRespiratory Syncytial Virus InfectionsAntibodies, MonoclonalAntibodies, ViralhMPVinfluenzamonoclonal antibodyRSV (respiratory syncytial virus)Streptococcus pnemoniae

Identifiers

PMID38933273
PMCPMC11199387

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.